Despite being clinically described 150 years ago, the mechanisms underlying amyotrophic
lateral sclerosis (ALS) pathogenesis have not yet been fully understood. Studies in both …

Amyotrophic lateral sclerosis is a disease affecting upper and lower motor neurons.
Although motor neuron death is the core event of ALS pathology, it is increasingly …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by
loss of motor neurons. The cause of disease is unknown other than in the rare cases of …

Amyotrophic lateral sclerosis is a complex disorder most of which is 'sporadic'of unknown
origin but approximately 10% is familial, arising from single mutations in any of more than 30 …

Amyotrophic lateral sclerosis (ALS), identified as a distinct clinical entity by Charcot since the
end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that …

Abstract Purpose of Review Amyotrophic lateral sclerosis (ALS) is a progressive
neurodegenerative disease for which there is no cure and treatments are at best palliative …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …

Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disease that targets
motor neurons (MNs) in the brain and spinal cord. It leads to gradual loss of motor signals to …

Amyotrophic lateral sclerosis (ALS) is an age-related neurodegenerative disorder that is
believed to have complex genetic and environmental influences in the pathogenesis, but …

Amyotrophic lateral sclerosis (ALS), first described by Jean-Martin Charcot in the 1870s, is
an age-related disorder that leads to degeneration of motor neurons. The disease begins …