Background Asthma is characterised by increased numbers of Th2-like cells in the airways
and IgE secretion. Generation of Th2 cells requires interleukin (IL)-4 and IL-13 acting …

Background: Asthma is associated with increased production of IL-4 and IL-13. Objective:
Because many of the effects of these cytokines are mediated by activation of signal …

Background The TH2‐type cytokines have been reported to contribute to the asthmatic
response. STAT6 has an essential role in IL‐4 signalling and in production of TH2 cytokines …

Antigen-specific CD4 T helper type 2 (Th2) cells play a pivotal role in the induction of allergic
asthma, but the mechanisms regulating their recruitment into the airways are unknown …

Signal transducers and activators of transcription 6 (STAT6) is essential for interleukin 4–
mediated responses, including class switching to IgE and induction of type 2 T helper cells …

Th2 cells induce asthma through the secretion of cytokines. Two such cytokines, IL-4 and IL-
13, are critical mediators of many features of this disease. They both share a common …

Background The allergen‐induced late nasal response is associated with a high local
expression of interleukin (IL)‐4, a TH2‐type cytokine implicated in immunoglobulin (Ig) E …

While signal transducer and activator of transcription protein 6 (STAT6) is important in
interleukin-4 (IL-4)-induced commitment of CD4+ T cells to the T helper cell, type 2 (Th2) …

It is well-recognized that Stat6 plays a critical role in Th2 cell differentiation and the induction
of allergic inflammation. We have previously shown that Stat5a is also required for Th2 cell …

The STAT3 transcription factor is critical for cytokine signaling and the acute phase
response, but its role in allergic asthma is largely undefined. To investigate the role of …