Melanin plays a role in determining human skin color of a person, and a large amount of
melanin makes the skin color look darkened. The proper amount of melanin formation …

Tyrosinase is a key player in ultraviolet-induced melanogenesis. Because excessive
melanin accumulation in the skin can induce hyperpigmentation, the development of …

Tyrosinase (TYR) is a key enzyme for melanin production. We previously showed that
hinokitiol, a naturally occurring seven-membered ring terpenoid, potently inhibits human …

The synthesis of melanin pigments or melanogenesis has many important physiological
functions that include photo protection of the human skin from ultraviolet (UV) irradiation …

Abstract Background In traditional Chinese medicine, the skin reflects the health of body
organs. A skin whitening agent, named seven whitening creams (also called Chi-Bai-San) …

As most of the available depigmenting agents exhibit only modest activity and some exhibit
toxicities that lead to adverse side effects after long‐term usage, there remains a need for …

Tyrosinase is a copper-containing key substance in the pigmentation of mammalian hair and
skin. Melanin synthesis is influenced by a variety of extrinsic and internal variables …

Tyrosinase is an important rate-limiting enzyme in melanin biosynthesis. To find potential
tyrosinase inhibitors with anti-melanogenic activity, a series of indole-thiazolidine-2, 4-dione …

2-(Naphthalen-1-ylmethylene) hydrazinecarbothioamide (14, IC50= 1.1 μM) was discovered
as a highly potent inhibitor of melanogenesis. To define the role of hydrogens (at N1 and …

Abstract Background 1-(2, 4-Dihydroxyphenyl)-3-(2, 4-dimethoxy-3-methylpheny) propane
(DP) was reported as a novel tyrosinase inhibitor by Nesterov et al. In previous study, we …