Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug delivery

AD Permana, F Nainu, K Moffatt… - Wiley …, 2021 - Wiley Online Library
Numerous diseases have been reported to affect the lymphatic system. As such, several
strategies have been developed to deliver chemotherapeutics to this specific network of …

Intradermal and transdermal drug delivery using microneedles–Fabrication, performance evaluation and application to lymphatic delivery

AH Sabri, Y Kim, M Marlow, DJ Scurr, J Segal… - Advanced drug delivery …, 2020 - Elsevier
The progress in microneedle research is evidenced by the transition from simple 'poke and
patch'solid microneedles fabricated from silicon and stainless steel to the development of …

Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs

AJ Harvey, SA Kaestner, DE Sutter, NG Harvey… - Pharmaceutical …, 2011 - Springer
Purpose The purpose of this research was to examine the pharmacokinetics (PK) of drug
uptake for microneedle-based intradermal (ID) delivery of several classes of protein drugs …

Microneedle‐Mediated Cell Therapy

Z Gao, T Sheng, W Zhang, H Feng, J Yu… - Advanced …, 2024 - Wiley Online Library
Microneedles have emerged as a promising platform for transdermal drug delivery with
prominent advantages, such as enhanced permeability, mitigated pain, and improved …

Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes

N Trac, EJ Chung - Experimental Biology and Medicine, 2021 - journals.sagepub.com
The lymph nodes are major sites of cancer metastasis and immune activity, and thus
represent important clinical targets. Although not as well-studied compared to subcutaneous …

Microneedle-based technology for cell therapy: current status and future directions

BZ Chen, ZQ Zhao, MA Shahbazi, XD Guo - Nanoscale Horizons, 2022 - pubs.rsc.org
With the growing technological innovations in medical treatments, cell-based therapies hold
great potential as efficient tools against various previously incurable diseases by restoring or …

Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery

Y Tang, B Liu, Y Zhang, Y Liu, Y Huang… - Advanced Drug Delivery …, 2024 - Elsevier
The lymphatic system has garnered significant attention in drug delivery research due to the
advantages it offers, such as enhancing systemic exposure and enabling lymph node …

Innovations in lymph node targeting nanocarriers

J Kim, PA Archer, SN Thomas - Seminars in immunology, 2021 - Elsevier
Lymph nodes are secondary lymphoid tissues in the body that facilitate the co-mingling of
immune cells to enable and regulate the adaptive immune response. They are also tissues …

The role of nanocarriers for transdermal application targeted to lymphatic drug delivery: Opportunities and challenges

TC De Oliveira, MEV Tavares… - Journal of Drug Delivery …, 2022 - Elsevier
The transdermal route is a promising drug delivery strategy as it is a non-invasive pathway. It
may provide a controlled drug release, with longer-lasting effects on the organism as it does …

Nano-sized drug delivery systems for lymphatic delivery

HY Cho, YB Lee - Journal of Nanoscience and …, 2014 - ingentaconnect.com
The lymphatic system plays important roles for immune responses, spreading cancer cells or
viruses and disseminating infections. Thus, targeting drugs, such as anticancer …