Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug delivery
AD Permana, F Nainu, K Moffatt… - Wiley …, 2021 - Wiley Online Library
Numerous diseases have been reported to affect the lymphatic system. As such, several
strategies have been developed to deliver chemotherapeutics to this specific network of …
strategies have been developed to deliver chemotherapeutics to this specific network of …
Intradermal and transdermal drug delivery using microneedles–Fabrication, performance evaluation and application to lymphatic delivery
The progress in microneedle research is evidenced by the transition from simple 'poke and
patch'solid microneedles fabricated from silicon and stainless steel to the development of …
patch'solid microneedles fabricated from silicon and stainless steel to the development of …
Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs
AJ Harvey, SA Kaestner, DE Sutter, NG Harvey… - Pharmaceutical …, 2011 - Springer
Purpose The purpose of this research was to examine the pharmacokinetics (PK) of drug
uptake for microneedle-based intradermal (ID) delivery of several classes of protein drugs …
uptake for microneedle-based intradermal (ID) delivery of several classes of protein drugs …
Microneedle‐Mediated Cell Therapy
Microneedles have emerged as a promising platform for transdermal drug delivery with
prominent advantages, such as enhanced permeability, mitigated pain, and improved …
prominent advantages, such as enhanced permeability, mitigated pain, and improved …
Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes
N Trac, EJ Chung - Experimental Biology and Medicine, 2021 - journals.sagepub.com
The lymph nodes are major sites of cancer metastasis and immune activity, and thus
represent important clinical targets. Although not as well-studied compared to subcutaneous …
represent important clinical targets. Although not as well-studied compared to subcutaneous …
Microneedle-based technology for cell therapy: current status and future directions
BZ Chen, ZQ Zhao, MA Shahbazi, XD Guo - Nanoscale Horizons, 2022 - pubs.rsc.org
With the growing technological innovations in medical treatments, cell-based therapies hold
great potential as efficient tools against various previously incurable diseases by restoring or …
great potential as efficient tools against various previously incurable diseases by restoring or …
Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery
Y Tang, B Liu, Y Zhang, Y Liu, Y Huang… - Advanced Drug Delivery …, 2024 - Elsevier
The lymphatic system has garnered significant attention in drug delivery research due to the
advantages it offers, such as enhancing systemic exposure and enabling lymph node …
advantages it offers, such as enhancing systemic exposure and enabling lymph node …
Innovations in lymph node targeting nanocarriers
Lymph nodes are secondary lymphoid tissues in the body that facilitate the co-mingling of
immune cells to enable and regulate the adaptive immune response. They are also tissues …
immune cells to enable and regulate the adaptive immune response. They are also tissues …
The role of nanocarriers for transdermal application targeted to lymphatic drug delivery: Opportunities and challenges
TC De Oliveira, MEV Tavares… - Journal of Drug Delivery …, 2022 - Elsevier
The transdermal route is a promising drug delivery strategy as it is a non-invasive pathway. It
may provide a controlled drug release, with longer-lasting effects on the organism as it does …
may provide a controlled drug release, with longer-lasting effects on the organism as it does …
Nano-sized drug delivery systems for lymphatic delivery
The lymphatic system plays important roles for immune responses, spreading cancer cells or
viruses and disseminating infections. Thus, targeting drugs, such as anticancer …
viruses and disseminating infections. Thus, targeting drugs, such as anticancer …
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