Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …
MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
Phenotypic characterization of genetically lowered human lipoprotein (a) levels
Background: Genomic analyses have suggested that the LPA gene and its associated
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …
A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk
T Kyriakou, U Seedorf, A Goel… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Increased levels of lipoprotein (a) are a highly heritable risk factor for coronary
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report
M Hoekstra, HY Chen, J Rong, L Dufresne… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …
and plasma levels are primarily determined by variation at the LPA locus. We performed a …
Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels
W Lu, YC Cheng, K Chen, H Wang… - Human molecular …, 2015 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms [S]
High lipoprotein (a)[Lp (a)] concentrations are an independent risk factor for cardiovascular
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …
Lipoprotein (a) is markedly more atherogenic than LDL: an apolipoprotein B-based genetic analysis
E Björnson, M Adiels, MR Taskinen, S Burgess… - Journal of the American …, 2024 - jacc.org
Abstract Background Lipoprotein (a)(Lp (a)) is recognized as a causal factor for coronary
heart disease (CHD) but its atherogenicity relative to that of low-density lipoprotein (LDL) on …
heart disease (CHD) but its atherogenicity relative to that of low-density lipoprotein (LDL) on …
Circulating lipoprotein (a) levels and health outcomes: Phenome-wide Mendelian randomization and disease-trajectory analyses
Abstract Background Lipoprotein (a)[Lp (a)] is a risk factor for atherosclerotic and valvular
diseases, but its possible role in other diseases has not yet been established. We conducted …
diseases, but its possible role in other diseases has not yet been established. We conducted …
Hyperlipidemia and cardiovascular disease: new insights on lipoprotein (a)
R Burkhardt - Current opinion in lipidology, 2019 - journals.lww.com
Elevated plasma level of LDL-cholesterol (LDL-C) is a modifiable major risk factor for
atherosclerotic cardiovascular disease. Several LDL-C-lowering agents successfully reduce …
atherosclerotic cardiovascular disease. Several LDL-C-lowering agents successfully reduce …
Genome-and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study
Abstract Lipoprotein (a)(Lp (a)) is an independent risk factor for cardiovascular disease. Lp
(a) levels in African Americans (AAs) are much higher compared with that in European …
(a) levels in African Americans (AAs) are much higher compared with that in European …