[HTML][HTML] Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer
T Stüber, R Monjezi, L Wallstabe… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Immunotherapy with chimeric antigen receptor (CAR)-engineered T-cells is
effective in some hematologic tumors. In solid tumors, however, sustained antitumor …
effective in some hematologic tumors. In solid tumors, however, sustained antitumor …
Novel RORgamma agonists enhance anti-tumor activity of adoptive T cell therapy (TUM2P. 1010)
L Carter, J Moisan, K Majchrzak, X Hu… - The Journal of …, 2015 - journals.aai.org
Adoptive cell transfer (ACT) therapy using tumor infiltrating lymphocytes (TILs) or T cells
modified to express chimeric antigen receptors is a promising anti-cancer approach …
modified to express chimeric antigen receptors is a promising anti-cancer approach …
Time limited exposure to a ROR1 targeting bispecific T cell engager (NVG-111) leads to durable responses in subjects with relapsed refractory chronic lymphocytic …
Background: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein
that is absent or expressed at low levels in normal adult tissues but overexpressed in a …
that is absent or expressed at low levels in normal adult tissues but overexpressed in a …
FOXO1 Inhibition Generates Potent Nonactivated CAR T Cells against Solid Tumors
M Marchais, L Simula, M Phayanouvong… - Cancer Immunology …, 2023 - AACR
Chimeric antigen receptor (CAR) T cells have shown promising results in the treatment of B-
cell malignancies. Despite the successes, challenges remain. One of them directly involves …
cell malignancies. Despite the successes, challenges remain. One of them directly involves …
Selective clearance of chronic lymphocytic leukemia cells in vivo following treatment with UC99961, an anti-ROR1 monoclonal antibody
E Hellqvist, CCN Wu, GF Widhopf II, A Shih, R Tawatao… - Blood, 2012 - Elsevier
Abstract 3886 ROR1 is a receptor-tyrosine kinase like protein expressed on the surface of
chronic lymphocytic leukemia (CLL) B cells, but not on normal mature B cells, suggesting …
chronic lymphocytic leukemia (CLL) B cells, but not on normal mature B cells, suggesting …
A sensitive and robust bioanalytical assay for pharmacokinetic analysis of ROR1xCD3 bispecific T cell engager (NVG-111) in a first-in-human study.
e19505 Background: Receptor tyrosine kinase-like Orphan Receptor-1 (ROR1) is widely
expressed on hematological and solid tumors. NVG-111, a first in class humanized tandem …
expressed on hematological and solid tumors. NVG-111, a first in class humanized tandem …
Preclinical safety, biodistribution, and tumor infiltration analysis of CAR T cell targets using in situ hybridization technology
H Pimentel, H Jarnagin, H Zong, C Todorov, K Ganley… - Cancer Research, 2019 - AACR
Chimeric antigen receptor (CAR) T cell therapy has proven to be highly effective in treating
hematologic malignancies, and major efforts are being made to achieve similar efficacy in …
hematologic malignancies, and major efforts are being made to achieve similar efficacy in …
LYL119, an investigational ROR1-targeted CAR T-cell product incorporating four novel reprogramming technologies designed for effective cell therapy for solid tumors
VC Lam, A Li, MG Casas, J Barragan, C Cheung… - Cancer Research, 2024 - AACR
Effective solid tumor cell therapy requires new strategies to improve T-cell activation,
persistence, and durable function. We developed four complementary T-cell reprogramming …
persistence, and durable function. We developed four complementary T-cell reprogramming …
IGF1R-and ROR1-Specific Chimeric Antigen Receptor (CAR) T Cell Immunotherapy for Poor Risk Sarcomas
H Park, X Huang, J Greene, J Pao, E Mulvey… - Biology of Blood and …, 2015 - tctjournal.org
Background Patients with metastatic or recurrent/refractory sarcomas have a dismal
prognosis with 5-year survival of 10-20%. IGF1R (insulin-like growth factor-1 receptor) is …
prognosis with 5-year survival of 10-20%. IGF1R (insulin-like growth factor-1 receptor) is …
Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR-1) Is Expressed in Low Grade NHL and B-CLL and Activates the Non Canonical Wnt Pathway
F Gibellini, CM Chapman, Y Herishanu, B Vire… - 2008 - ashpublications.org
ROR-1, an orphan receptor tyrosine kinase (RTK) carrying an extracellular WNT binding
motif, is highly expressed in many tissues during development. Expression of ROR-1 in …
motif, is highly expressed in many tissues during development. Expression of ROR-1 in …