[HTML][HTML] Development of human recombinant antibodies against ROR1 tumor antigen
Background: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal
antigen expressed on many types of cancer cells, but not normal adult cells. ROR1 antigen …
antigen expressed on many types of cancer cells, but not normal adult cells. ROR1 antigen …
ROR1 for Lymphoid Cancers
SJ Schuster - NEJM evidence, 2022 - evidence.nejm.org
ROR1 for Lymphoid Cancers | NEJM Evidence Skip to main content NEJM Evidence homepage
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Inhibition of the receptor tyrosine kinase ROR1 by anti-ROR1 monoclonal antibodies and siRNA induced apoptosis of melanoma cells
M Hojjat-Farsangi, F Ghaemimanesh… - PloS one, 2013 - journals.plos.org
The receptor tyrosine kinase (RTK) ROR1 is overexpressed and of importance for the
survival of various malignancies, including lung adenocarcinoma, breast cancer and chronic …
survival of various malignancies, including lung adenocarcinoma, breast cancer and chronic …
[HTML][HTML] A Novel Humanised ROR1 Bi-Specific T-Cell Engager Molecule for the Treatment of Chronic Lymphocytic Leukaemia
SH Gohil, M Harrasser, SR Paredes-Moscosso… - Blood, 2016 - Elsevier
Abstract Bispecific T-cell Engagers (BiTEs) are a promising immunotherapeutic approach,
usually consisting of two single chain variable fragments (scFv) linked in tandem. One arm …
usually consisting of two single chain variable fragments (scFv) linked in tandem. One arm …
Anti-ROR1 x anti-CD3 ADAPTIR™ molecule, ES425, redirects T-cell cytotoxicity and inhibits tumor growth in preclinical models of triple-negative breast cancer
JW Blankenship, L Misher, D Mitchell, N Zhang, P Tan… - Cancer Research, 2016 - AACR
Background: Effective treatment of metastatic, triple-negative breast cancer (TNBC) remains
a highly unmet medical need. We have developed ES425, a bispecific ADAPTIR™(modular …
a highly unmet medical need. We have developed ES425, a bispecific ADAPTIR™(modular …
Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell …
DC Deniger, J Yu, MH Huls, MJ Figliola, T Mi, SN Maiti… - PloS one, 2015 - journals.plos.org
T cells modified with chimeric antigen receptors (CARs) targeting CD19 demonstrated
clinical activity against some B-cell malignancies. However, this is often accompanied by a …
clinical activity against some B-cell malignancies. However, this is often accompanied by a …
Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1
T cell-engaging bispecific antibodies (biAbs) present a promising strategy for cancer
immunotherapy, and numerous bispecific formats have been developed for retargeting …
immunotherapy, and numerous bispecific formats have been developed for retargeting …
Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications
RS Goydel, J Weber, H Peng, J Qi, J Soden… - Journal of Biological …, 2020 - ASBMB
Antibodies are widely used as cancer therapeutics, but their current use is limited by the low
number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine …
number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine …
[PDF][PDF] LYL119, a Preclinical ROR1-Targeted CAR T-Cell Product Incorporating Four Novel Reprogramming Technologies Designed to Enable Functional Cell …
VC Lam, C Cheung, G Vavra, R Martinez, C Sims… - lyell.com
LYL119, a Preclinical ROR1-Targeted CAR T-Cell Product Incorporating Four Novel
Reprogramming Technologies Designed to Enable Fu Page 1 AACR 2024 | April 7-10; San …
Reprogramming Technologies Designed to Enable Fu Page 1 AACR 2024 | April 7-10; San …
NVG-111, a novel ROR1xCD3 bispecific antibody for non-Hodgkin lymphoma.
D Granger, S Gohil, A Barbarulo, A Baccaro… - 2021 - ascopubs.org
7549 Background: Receptor tyrosine kinase-like Orphan Receptor 1 (ROR1) is a type I
transmembrane protein is highly expressed on an array of haematological and solid …
transmembrane protein is highly expressed on an array of haematological and solid …