Klotho as a regulator of oxidative stress and senescence
M Kuro-o - 2008 - degruyter.com
The klotho gene functions as an aging-suppressor gene that extends life span when
overexpressed and accelerates aging-like phenotypes when disrupted in mice. The klotho …
overexpressed and accelerates aging-like phenotypes when disrupted in mice. The klotho …
[HTML][HTML] Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients
MS Buiten, MK de Bie, A Bouma-de Krijger, B van Dam… - BMC nephrology, 2014 - Springer
Background Dialysis patients suffer from a high burden of cardiovascular disease (CVD).
Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous …
Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous …
[HTML][HTML] Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis
SV Madathil, LM Coe, C Casu, D Sitara - The American journal of …, 2014 - Elsevier
Klotho deficiency is a characteristic feature of chronic kidney disease in which anemia and
cardiovascular complications are prevalent. Disruption of the Klotho gene in mice results in …
cardiovascular complications are prevalent. Disruption of the Klotho gene in mice results in …
The biological role of klotho protein in the development of cardiovascular diseases
A Olejnik, A Franczak… - BioMed research …, 2018 - Wiley Online Library
Klotho is a membrane‐bound or soluble antiaging protein, whose protective activity is
essential for a proper function of many organs. In 1997, an accidental insertion of a …
essential for a proper function of many organs. In 1997, an accidental insertion of a …
Fibroblast growth factor 23/klotho axis in chronic kidney disease
K Nitta, N Nagano, K Tsuchiya - Nephron Clinical Practice, 2014 - karger.com
Abstract Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates
phosphate and 1, 25-hydroxyvitamin D [1, 25 (OH) 2 D] metabolism. FGF23 binds to FGF …
phosphate and 1, 25-hydroxyvitamin D [1, 25 (OH) 2 D] metabolism. FGF23 binds to FGF …
[HTML][HTML] Klotho and mesenchymal stem cells: a review on cell and gene therapy for chronic kidney disease and acute kidney disease
Chronic kidney disease (CKD) and acute kidney injury (AKI) are public health problems, and
their prevalence rates have increased with the aging of the population. They are associated …
their prevalence rates have increased with the aging of the population. They are associated …
[HTML][HTML] Indoxyl sulfate enhance the hypermethylation of klotho and promote the process of vascular calcification in chronic kidney disease
J Chen, X Zhang, H Zhang, T Liu, H Zhang… - … journal of biological …, 2016 - ncbi.nlm.nih.gov
Chronic kidney disease (CKD) is a state of Klotho deficiency. The Klotho expression may be
suppressed due to DNA hypermethylation in cancer cells so we have investigated the effects …
suppressed due to DNA hypermethylation in cancer cells so we have investigated the effects …
Soluble Klotho and incident hypertension
Results The median klotho concentration was 630 pg/ml (478–816, 25th to 75th percentile).
Within the cohort, 2093 (76%) of 2774 participants had prevalent hypertension and 476 …
Within the cohort, 2093 (76%) of 2774 participants had prevalent hypertension and 476 …
In Vivo klotho Gene Transfer Ameliorates Angiotensin II-Induced Renal Damage
H Mitani, N Ishizaka, T Aizawa, M Ohno, S Usui… - …, 2002 - Am Heart Assoc
The klotho gene, originally identified by insertional mutagenesis in mice, suppresses the
expression of multiple aging-associated phenotypes. This gene is predominantly expressed …
expression of multiple aging-associated phenotypes. This gene is predominantly expressed …