Objective: To investigate the effects of estrogen on left ventricle (LV) mass and collagen
deposition, and on the expression of receptors for estrogen (ERα, ERβ) and Ang II (AT2R …

Background—Left ventricular hypertrophy (LVH) displays significant gender-based
differences. 17β-estradiol (E2) plays an important role in this process because it can …

Premenopausal women are much less prone to develop cardiovascular disease than men of
similar age, but this advantage no longer applies after menopause. We previously found that …

Background—Estrogen may increase the long-term survival of women who have suffered
from a myocardial infarction (MI). We examined the acute and chronic influence of estrogen …

We have previously reported gender differences in ventricular remodeling and development
of heart failure using the aortocaval fistula model of chronic volume overload in rats. In …

The importance of endogenous and exogenous estrogen levels to the development of
cardiovascular disease in women in controversial. The purpose of our study was to examine …

Diastolic dysfunction is more prevalent in individuals with hypertension, particularly
postmenopausal women; however, the pathogenesis of diastolic dysfunction remains …

Experimental studies showed that 17β-estradiol (E2) and activated Estrogen Receptors (ER)
protect the heart from ischemic injury. However, the underlying molecular mechanisms are …

To elucidate the molecular mechanism underlying estrogen-mediated cardioprotection in left
ventricular (LV) hypertrophy and remodeling, we analyzed myocardial hypertrophy as well …

Objectives Prognosis of heart failure remains poor despite therapeutic advances, such as
angiotensin converting enzyme inhibition or β-receptor blockade. Thus, more effective forms …