Insulin-like growth factor (IGF) bioavailability is modulated by specific IGFBPs, six of which
are known (IGFBPs 1–6). Since IGFBPs have equal or higher affinity for IGFs than do IGF …

Insulin-like growth factor binding protein-3 (IG-FBP-3) is degraded by a Zn (2+)-dependent
protease (s) produced by human dermal fibroblasts in vitro (Fowlkes, J.(1994) Endocrine J …

Binding of IGF-I or IGF-II by high-affinity IGF-binding proteins (IGFBPs) sequesters IGFs,
preventing their interactions with cell surface IGF receptors. Hypothetically, IGFs might be …

Insulin-like growth factor (IGF)-binding protein-5 (IGFBP-5) is uniquely regulated throughout
MC3T3-E1 osteoblast differentiation: IGFBP-5 is first detectable in conditioned medium (CM) …

Insulin-like growth factor binding protein-3 (IGFBP-3) is degraded by a cation-dependent
protease (s) present in the serum of late gestation rats. Proteolysis of IGFBP-3 results in an …

Previous studies have shown that insulin-like growth factor (IGF)-binding protein-4 (IGFBP-
4) is degraded only in the presence of exogenous IGFs; however, we found that cation …

In biologic fluids, insulinlike growth factors (IGF-I and IGF-II) are bound to high-affinity
insulinlike growth factor binding proteins (IGFBPs) of which seven have now been identified …

IGF Binding Protein-3 (IGFBP-3), the major IGF carrier in the blood, undergoes limited
proteolysis which reduces its affinity for IGFs, thus facilitating dissociation. The functional …

The mechanisms by which insulin-like growth factors (IGFs) reduce IGF-binding protein-4
(IGFBP-4) levels in cellular conditioned media are poorly understood. The effect of IGFs on …

Insulin-like growth factor binding proteins (IGFBP) proteases have been proposed to be
involved in changes of serum IGFBP pattern during pregnancy. IGFBP-4 and-5 are …