Third Harmonic Generation microscopy distinguishes malignant cell grade in human breast tissue biopsies

E Gavgiotaki, G Filippidis, V Tsafas, S Bovasianos… - Scientific reports, 2020 - nature.com
The ability to distinguish and grade malignant cells during surgical procedures in a fast, non-
invasive and staining-free manner is of high importance in tumor management. To this …

Non‐invasive multiphoton imaging of extracellular matrix structures

K Schenke‐Layland - Journal of biophotonics, 2008 - Wiley Online Library
Multiphoton microscopy has become a powerful method for the artifact‐free, nondestructive
evaluation of deep‐tissue cells and extracellular matrix (ECM) structures in their native …

Changes of collagen ultrastructure in breast cancer tissue determined by second-harmonic generation double Stokes-Mueller polarimetric microscopy

A Golaraei, L Kontenis, R Cisek, D Tokarz… - Biomedical optics …, 2016 - opg.optica.org
Second-harmonic generation (SHG) double Stokes-Mueller polarimetric microscopy is
applied to study the alteration of collagen ultrastructure in a tissue microarray containing …

Elastic fibers and collagen distribution in human aorta

G Vieira-Damiani, DP Ferro, RL Adam… - … Microscopy in the …, 2011 - spiedigitallibrary.org
Elastic and collagen fibers are essential components of the aorta, the remodeling of these
structures is accompanied with aging in various diseases and life-threatening events. While …

Characterization of pathological thyroid tissue using polarization-sensitive second harmonic generation microscopy

D Tokarz, R Cisek, A Joseph, SL Asa… - Laboratory …, 2020 - nature.com
Polarization-sensitive second harmonic generation (SHG) microscopy is an established
imaging technique able to provide information related to specific molecular structures …

Second harmonic generation microscopy as a powerful diagnostic imaging modality for human ovarian cancer

J Adur, VB Pelegati, AA de Thomaz… - Journal of …, 2014 - Wiley Online Library
In this study we showed that second‐harmonic generation (SHG) microscopy combined with
precise methods for images evaluation can be used to detect structural changes in the …

Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections

A Tuer, D Tokarz, N Prent, R Cisek… - … of biomedical optics, 2010 - spiedigitallibrary.org
Imaging hematoxylin-and-eosin-stained cancerous histological sections with multicontrast
nonlinear excitation fluorescence, second-and third-harmonic generation (THG) microscopy …

Imaging rat esophagus using combination of reflectance confocal and multiphoton microscopy

SM Zhuo, JX Chen, XS Jiang, KC Lu… - Laser Physics …, 2008 - iopscience.iop.org
We combine reflectance confocal microscopy (RCM) with multiphoton microscopy (MPM) to
image rat esophagus. The two imaging modalities allow detection of layered–resolved …

Imaging normal and cancerous human gastric muscular layer in transverse and longitudinal sections by multiphoton microscopy

Y Zhou, D Kang, Z Yang, L Li, S Zhuo, X Zhu… - …, 2016 - Wiley Online Library
Multiphoton microscopy (MPM) based on two‐photon excited fluorescence (TPEF) and
second harmonic generation (SHG) has been widely used for imaging microstructure of …

Unsupervised determination of lung tumor margin with widefield polarimetric second-harmonic generation microscopy

K Mirsanaye, L Uribe Castaño, Y Kamaliddin… - Scientific reports, 2022 - nature.com
The extracellular matrix (ECM) is amongst many tissue components affected by cancer,
however, morphological changes of the ECM are not well-understood and thus, often …