Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome
(ARDS), have high mortality rates with few treatment options. An important regulatory factor …

Hyaluronan (HA) has diverse functions in normal lung homeostasis and pulmonary disease.
HA constitutes the major glycosaminoglycan in lung tissue, with HA degradation products …

Asthma is frequently caused and/or exacerbated by sensitization to allergens, which are
ubiquitous in many indoor and outdoor environments. Severe asthma is characterized by …

Background Several inflammatory lung diseases display abundant presence of hyaluronic
acid (HA) bound to heavy chains (HC) of serum protein inter-alpha-inhibitor (IαI) in the …

Hyaluronan is a hygroscopic glycosaminoglycan that contributes to both extracellular and
pericellular matrices. While the production of hyaluronan is essential for mammalian …

Hyaluronan, a ubiquitous naturally occurring glycosaminoglycan, is a major component of
the extracellular matrix, where it participates in biological processes that include water …

Lung endothelial permeability is a key pathological feature of acute respiratory distress
syndrome. Hyaluronic acid (HA), a major component of the glycocalyx layer on the …

In normal airways, hyaluronan (HA) matrices are primarily located within the airway
submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. Following …

Despite many decades of active research and several clinical treatment trials, acute lung
injury (ALI)/acute respiratory distress syndrome remains a severe complication of …

Hyaluronan in acute respiratory distress syndrome (ARDS): simply a biomarker or a deeper
insight into ARDS mechanisms? - Lonati - Journal of Laboratory and Precision Medicine Have …