Gene-based therapies, including the delivery of oligonucleotides, offer promising methods
for the treatment of cancer cells. However, they have various limitations including low …

Abstract Magnetic nanoparticles (MNPs, Fe3O4) incorporated into the complexes of cell
penetrating peptides (CPPs)-oligonucleotides (ONs) promoted the cell transfection for …

In this study, a novel multi-targeted magnetic nanoparticles (MTMNPs) are synthesized to
investigate their potential application in DNA protection and targeted gene delivery to breast …

Cancer gene therapy involves the replacement of missing or altered genes with healthy
ones. In this paper, we have proposed tumor suppressor gene-carrying superparamagnetic …

The aim of this study was to synthesize a chitosan (CS) derivative, a quaternary ammonium
salt crystal called N-2-hydroxypropyl trimethyl ammonium chloride chitosan (HACC), and …

Chitosan (CS)/DNA complex nanoparticles (NPs) have been considered as a vector for
gene delivery. Although advantageous for DNA packing and protection, CS-based …

The ideal gene polyplexes should have a subtle balance between polyplex stability to
protect DNA against nucleases, and polyplex instability to permit DNA dissociation inside …

Herein, we report an easy and ingenious method to functionalize magnetic iron oxide
nanoparticles (MNPs) with plasmid DNA (pDNA) to obtain nanohybrid systems suitable for …

CXC chemokine receptor 4 (CXCR4) is a promising therapeutic target. Previous studies
have shown that intracellular delivery of siRNA to knockdown CXCR4 expression in cancer …

The structure–activity relationships between hydrophobic and hydrophilic modification on
chitosan and resultant physicochemical properties along with performances in dealing with …