The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …

DNA methylation in mammals is a key epigenetic modification essential to normal genome
regulation and development. DNA methylation patterns are established during early …

Epigenetic modification of the cytosine base of DNA by its methylation introduced the
possibility that beyond the inherent information contained within the nucleotide sequence …

Methylation of cytosines and adenines in DNA is a widespread epigenetic mark in both
prokaryotes and eukaryotes. In eukaryotes, it has a profound influence on chromatin …

Cytosine methylation in mammals is an epigenetic modification required for viability of the
developing embryo. It has been suggested that DNA methylation plays important roles in X …

We used mouse embryonic stem (ES) cells with systematic gene knockouts for DNA
methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a …

Methylation of cytosines (5meC) is a widespread heritable DNA modification. During
mammalian development, two global demethylation events are followed by waves of de …

DNA methylation: A molecular lock: Current Biology Skip to Main Content Advertisement Current
Biology This journal offers authors two options (open access or subscription) to publish research …

The DNA methyltransferases (Dnmts) are responsible for the generation of genomic
methylation patterns, which lead to transcriptional silencing. Recent studies have identified …

The methylation of mammalian DNA, primarily at CpG dinucleotides, has long been
recognized to play a major role in controlling gene expression, among other functions. Given …