Export of mRNA through nuclear pore complexes (NPC) is preceded by multiple and well
coordinated processing steps, resulting in the formation of an export competent …

Cellular mRNAs are produced in the nucleus and must be exported to the cytoplasm to allow
for their translation into proteins. Recruitment of export factors to nascent mRNA starts …

Fully processed mRNAs are exported to the cytoplasm where they direct protein synthesis. A
general feature of mRNA export is that it is an active, receptor-mediated process. The mRNA …

The genetic information encoded in nuclear mRNA destined to reach the cytoplasm requires
the interaction of the mRNA molecule with the nuclear pore complex (NPC) for the process …

Eukaryotic cells massively exchange macromolecules (proteins and RNAs) between the
nucleus and cytoplasm through the nuclear pore complexes. Whereas a mechanistic picture …

Export of mRNA from the nucleus to the cytoplasm is a critical process for all eukaryotic gene
expression. As mRNA is synthesized, it is packaged with a myriad of RNA‐binding proteins …

Activation of the gene expression pathway in eukaryotic cells results in the nuclear
transcription of mRNA molecules, many of which are destined for translation into protein by …

The evolutionary 'decision'to store genetic information away from the place of protein
synthesis, in a separate compartment, has forced eukaryotic cells to establish a system to …

From decades of genetic and molecular studies, there is no doubt about the foremost
importance of genes in defining organism and cell identity, in healthy and in pathological …

mRNAs are transported from the nucleus to the cytoplasm by a machinery conserved from
yeast to humans. Previous studies showed that mRNA export factors are loaded on nascent …