Fibroblast growth factor receptor inhibitors as a cancer treatment: from a biologic rationale to medical perspectives
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling pathway
plays a fundamental role in many physiologic processes, including embryogenesis, adult …
plays a fundamental role in many physiologic processes, including embryogenesis, adult …
Fibroblast growth factor (FGF) receptor/FGF inhibitors: novel targets and strategies for optimization of response of solid tumors
C Hierro, J Rodon, J Tabernero - Seminars in oncology, 2015 - Elsevier
The fibroblast growth factor receptor (FGFR) pathway plays a major role in several biological
processes, from organogenesis to metabolism homeostasis and angiogenesis. Several …
processes, from organogenesis to metabolism homeostasis and angiogenesis. Several …
[HTML][HTML] Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application
YK Chae, K Ranganath, PS Hammerman, C Vaklavas… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) is a tyrosine kinase
signaling pathway that has a fundamental role in many biologic processes including …
signaling pathway that has a fundamental role in many biologic processes including …
Future applications of FGF/FGFR inhibitors in cancer
Introduction: Deregulation of the fibroblast growth factor (FGF)/FGF receptor (FGFR) network
occurs frequently in tumors due to gene amplification, activating mutations, and oncogenic …
occurs frequently in tumors due to gene amplification, activating mutations, and oncogenic …
Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer
AN Brooks, E Kilgour, PD Smith - Clinical cancer research, 2012 - AACR
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays
an important role in normal organ, vascular, and skeletal development. Deregulation of …
an important role in normal organ, vascular, and skeletal development. Deregulation of …
Targeting FGFR signaling in cancer
The fibroblast growth factor signaling pathway (FGFR signaling) is an evolutionary
conserved signaling cascade that regulates several basic biologic processes, including …
conserved signaling cascade that regulates several basic biologic processes, including …
Small molecule inhibition of fibroblast growth factor receptors in cancer
G Liang, G Chen, X Wei, Y Zhao, X Li - Cytokine & growth factor reviews, 2013 - Elsevier
Fibroblast growth factors (FGFs) signal through FGF receptors (FGFRs), which are a sub-
family of the superfamily of receptor tyrosine kinases, to regulate human development and …
family of the superfamily of receptor tyrosine kinases, to regulate human development and …
Biological significance and targeting of the FGFR axis in cancer
AM Chioni, RP Grose - Cancers, 2021 - mdpi.com
Simple Summary All cells within tissues and organ systems must communicate with each
other to ensure they function in a coordinated manner. One form of communication is …
other to ensure they function in a coordinated manner. One form of communication is …
Targeting the fibroblast growth factor receptor family in cancer
Fibroblast growth factors (FGFs) regulate a plethora of biological functions, in both the
embryonic and adult stages of development, binding their cognate receptors and thus …
embryonic and adult stages of development, binding their cognate receptors and thus …
The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis
Introduction: Fibroblast growth factors (FGFs) are endowed with a potent pro-angiogenic
activity. Activation of the FGF/FGF receptor (FGFR) system occurs in a variety of human …
activity. Activation of the FGF/FGF receptor (FGFR) system occurs in a variety of human …