The placenta is one of the most important yet least understood organs. Due to the limitations
of conventional research approaches, we are still far from a comprehensive understanding …

The adult human brain comprises more than a thousand distinct neuronal and glial cell
types, a diversity that emerges during early brain development. To reveal the precise …

Using ultrasound-guided in utero infections of fluorescently traceable lentiviruses carrying
RNAi or Cre recombinase into mouse embryos, we have demonstrated noninvasive, highly …

Here, we provide fundamental insights into early human development by single-cell RNA-
sequencing of human and mouse preimplantation embryos. We elucidate conserved …

It remains an open question when and how the first cell fate decision is made in mammals.
Using deep single-cell RNA-seq of matched sister blastomeres, we report highly …

Mechanisms of initial cell fate decisions differ among species. To gain insights into lineage
allocation in humans, we derived ten human embryonic stem cell lines (designated UCSFB1 …

Here we delineate the ontogeny of the mammalian endoderm by generating 112,217 single-
cell transcriptomes, which represent all endoderm populations within the mouse embryo …

The body plan of the mammalian embryo is shaped through the process of gastrulation, an
early developmental event that transforms an isotropic group of cells into an ensemble of …

Single-cell epigenome sequencing techniques have recently been developed. However, the
combination of different layers of epigenome sequencing in an individual cell has not yet …

Lineage tracing and fate mapping, overlapping yet distinct disciplines to follow cells and
their progeny, have evolved rapidly over the last century. Lineage tracing aims to identify all …