A new type of interaction in which fruit juices diminish oral drug bioavailability through
inhibition of uptake transport is the focus of this review. The discovery was based on an …

The goals of this study were to assess the extent of human intestinal drug transporter
expression, determine the subcellular localization of the drug uptake transporter OATP1A2 …

Grapefruit juice produces mechanism‐based inhibition of intestinal drug metabolism when
consumed in normal quantities. This can produce clinically important increases in oral drug …

Objectives The purpose of this study was to elucidate the potential clinical relevance and
mechanism (s) of action of 2 different volumes of grapefruit juice on the reduction of …

Objectives Our objective was to examine the effect of different fruits and their constituents on
P‐glycoprotein and organic anion transporting polypeptide (OATP) activities in vitro and on …

Grapefruit juice is widely recognized to cause important drug interactions via inhibition of
CYP3A4, and a wider variety of fruit juices have been shown to inhibit influx transporters in …

Fexofenadine has been identified as a substrate for both the efflux transporter, P-
glycoprotein (P-gp), as well as the influx transporter, organic anion transporting polypeptide …

We showed previously that grapefruit and orange juices inhibited human enteric organic
anion‐transporting polypeptide (OATP) 1A2 in vitro and lowered oral fexofenadine …

Concomitant administration of grapefruit juice can increase the plasma concentration of
numerous drugs in humans and decrease the concentration of a few others. Such elevations …

Recently there has been speculation regarding prescription drug interactions with fruit
beverages through inhibition of drug uptake transport by organic anion transporter …