Activating mutations of the BRAF gene are the most common genetic alterations in papillary
thyroid carcinomas (PTCs) and the T1799A transversion, resulting in BRAF V600E …

An activating mutation in the BRAF gene is the most common genetic alteration in papillary
thyroid carcinomas (PTCs). The mutation in PTCs is almost a c. 1799T> A transversion …

Context: Mutations in BRAF are rare in the follicular variant of papillary thyroid carcinoma
(FV-PTC). Objective: We identified and functionally characterized a novel T599I-VKSR (600 …

BRAF gene mutations have been frequently detected in papillary thyroid carcinoma (PTC).
Moreover, there is a close association between the type of mutation and the PTC histotype …

To assess the mutational status of BRAF in FVPTC, we directly sequenced the genomic DNA
of 30 primary FVPTC samples. BRAF mutations were found in only 4 (13%) tumors. We also …

BRAF exon 15 mutations are the most common molecular alterations found in papillary
thyroid carcinoma (PTC). To date, there is no information regarding BRAF alterations in the …

BRAF gene mutations are identified in about 45% of papillary thyroid carcinomas (PTC) and
represent the most common genetic event in this tumor. Here, we report a case of PTC, solid …

Introduction Activating mutations of the BRAF oncogene are frequently detected in papillary
thyroid carcinoma (PTC) and have been associated with a worse prognosis. The amino acid …

BRAF, a cytoplasmic serine–threonine protein kinase, plays a critical role in cell signaling as
an activator within the mitogen-activated protein kinase (MAPK) pathway. The most common …

Purpose: Oncogenic conversion of BRAF occurs in∼ 44% of papillary thyroid carcinomas
and 24% of anaplastic thyroid carcinomas. In papillary thyroid carcinomas, this mutation is …