BRAF T1796A Transversion Mutation in Various Thyroid Neoplasms
A high prevalence of activating mutation of the B type Raf kinase (BRAF) gene was recently
reported in papillary thyroid cancer (PTC). However, the frequency of this mutation in several …
reported in papillary thyroid cancer (PTC). However, the frequency of this mutation in several …
Detection of BRAF V600E activating mutation in papillary thyroid carcinoma using PCR with allele-specific fluorescent probe melting curve analysis
LR Rowe, BG Bentz, JS Bentz - Journal of clinical pathology, 2007 - jcp.bmj.com
Background: A single hotspot mutation at nucleotide 1799 of the BRAF gene has been
identified as the most common genetic event in papillary thyroid carcinoma (PTC), with a …
identified as the most common genetic event in papillary thyroid carcinoma (PTC), with a …
Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness
V Trovisco, P Soares, A Preto, IV de Castro, J Lima… - Virchows Archiv, 2005 - Springer
A high prevalence of the BRAF V600E somatic mutation was recently reported in several
series of papillary thyroid carcinomas (PTC). This mutation appears to be particularly …
series of papillary thyroid carcinomas (PTC). This mutation appears to be particularly …
[HTML][HTML] Comparison of diagnostic methods for the detection of a BRAF mutation in papillary thyroid cancer
J Zhao, P Liu, Y Yu, J Zhi, X Zheng… - Oncology …, 2019 - spandidos-publications.com
The most common genetic alteration identified in papillary thyroid cancer (PTC) encodes a
valine to glutamic acid change at position 600 (V600E) in the BRAF proto‑oncoprotein. The …
valine to glutamic acid change at position 600 (V600E) in the BRAF proto‑oncoprotein. The …
Lack of association between BRAF V600E mutation and mitogen‐activated protein kinase activation in papillary thyroid carcinoma
H Zuo, Y Nakamura, H Yasuoka, P Zhang… - Pathology …, 2007 - Wiley Online Library
The BRAF V600E mutation has been identified in a high proportion of papillary thyroid
carcinoma (PTC). In cell lines and a transgenic mouse model it has been demonstrated that …
carcinoma (PTC). In cell lines and a transgenic mouse model it has been demonstrated that …
Correlation between BRAF mutation and the clinicopathological parameters in papillary thyroid carcinoma with particular reference to follicular variant
RA Smith, A Salajegheh, S Weinstein, M Nassiri… - Human pathology, 2011 - Elsevier
Mutation of the BRAF gene is common in thyroid cancer. Follicular variant of papillary thyroid
carcinoma is a variant of papillary thyroid carcinoma that has created continuous diagnostic …
carcinoma is a variant of papillary thyroid carcinoma that has created continuous diagnostic …
[PDF][PDF] Extensive clinical experience: association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid …
C Lupi, R Giannini, C Ugolini, A Proietti… - Journal of Clinical …, 2007 - researchgate.net
Objective: We examined BRAF mutations in a consecutive series of 500 PTC patients who
underwent surgery in the Department of Surgery of the University of Pisa, and we correlated …
underwent surgery in the Department of Surgery of the University of Pisa, and we correlated …
Clinical significance of BRAF (V600E) mutation and Ki-67 labeling index in papillary thyroid carcinomas
H Nakayama, A Yoshida, Y Nakamura… - Anticancer …, 2007 - ar.iiarjournals.org
Background: Activating mutations of the BRAF gene have recently been reported in thyroid
carcinomas. In particular, V600E mutation is highly prevalent in papillary thyroid carcinoma …
carcinomas. In particular, V600E mutation is highly prevalent in papillary thyroid carcinoma …
Conditional BRAFV600E Expression Induces DNA Synthesis, Apoptosis, Dedifferentiation, and Chromosomal Instability in Thyroid PCCL3 Cells
N Mitsutake, JA Knauf, S Mitsutake, C Mesa Jr, L Zhang… - Cancer research, 2005 - AACR
The activating mutation BRAF T1796A is the most prevalent genetic alteration in papillary
thyroid carcinomas (PTC). It is associated with advanced PTCs, suggesting that this …
thyroid carcinomas (PTC). It is associated with advanced PTCs, suggesting that this …
[PDF][PDF] Functional Characterization of the T1799-1801del and G1799-1816ins BRAF Mutations in Papillary Thyroid Cancer
P Hou, D Liu, M Xing - Cell cycle, 2007 - Taylor & Francis
The RAS→ RAF→ MEK→ MAP kinase/ERK signaling pathway (MAP kinase pathway) is a
conserved protein kinase cascade that regulates cell growth, proliferation, and differentiation …
conserved protein kinase cascade that regulates cell growth, proliferation, and differentiation …