Background: The association of BRAFV600E with the clinical manifestations of papillary
thyroid carcinoma (PTC) remains controversial. Recent studies have shown that the BRAF …

The B-type Raf kinase (BRAF) protein is a serine/threonine kinase that has an important role
in cellular proliferation, differentiation, and programmed cell death. The BRAF gene has …

The activating mutation BRAF T1796A is the most prevalent genetic alteration in papillary
thyroid carcinomas (PTC). It is associated with advanced PTCs, suggesting that this …

In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has
received enthusiastic investigation, and significant progress has been made toward …

Somatic mutations in BRAF, especially BRAFV600E, are frequently identified in papillary
thyroid cancer (PTC) tumors. It has been established that expression levels of numbers of …

Context: BRAFV600E is considered a primary event, a negative prognostic marker, and a
site for pharmacological intervention in papillary thyroid carcinoma (PTC). We asked …

Background: BRAF mutation is the most common genetic event in papillary thyroid
carcinoma (PTC); however, the prevalence and patterns of the mutation vary worldwide. We …

BRAF is a serine/threonine kinase that receives a mitogenic signal from RAS and transmits it
to the MAP kinase pathway. Recent studies have reported that mutations of the BRAF gene …

Summary Purpose BRAF V600E mutation represents the most common oncogenic event in
sporadic papillary thyroid cancer (PTC). There are, however, significant discrepancies …

1. ABSTRACT BRAF is a cytoplasmic serine-threonine protein kinasethat plays a critical role
in the MAPK signaling pathway. BRAF is the only member of the RAF family activated by …