Oroxyloside ameliorates acetaminophen-induced hepatotoxicity by inhibiting JNK related apoptosis and necroptosis

Y Liao, Y Yang, X Wang, M Wei, Q Guo… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Oroxyloside is a natural flavonoid isolated from Scutellaria
baicalensis Georgi (Lamiaceae) which is a Chinese herb widely used for liver diseases …

γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways

G Shu, Y Qiu, J Hao, Q Fu, X Deng - Food & function, 2019 - pubs.rsc.org
Acetaminophen (APAP) overdose is a major cause of drug-induced liver injury worldwide.
Our current study was performed to assess the potential protective effects of γ-oryzanol …

Orostachys japonicus ameliorates acetaminophen-induced acute liver injury in mice

Z Zhou, J Qi, J Zhao, JH Seo, DG Shin, JD Cha… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Orostachys japonicus A. Berger (O. japonicus), referred to
as Wa-song in Korea is a traditional and herbal medicine. Even though it has been …

Attenuating oxidative stress by paeonol protected against acetaminophen-induced hepatotoxicity in mice

Y Ding, Q Li, Y Xu, Y Chen, Y Deng, F Zhi, K Qian - PLoS One, 2016 - journals.plos.org
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver
failure. The purpose of this study was to investigate whether paeonol protected against …

Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via …

J Wan, G Kuang, L Zhang, R Jiang, Y Chen… - International …, 2020 - Elsevier
Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …

Kaempferol sophoroside glucoside mitigates acetaminophen-induced hepatotoxicity: Role of Nrf2/NF-κB and JNK/ASK-1 signaling pathways

GA Mohamed, DS El-Agamy, HM Abdallah, IA Sindi… - Heliyon, 2024 - cell.com
APAP (Acetaminophen)-induced hepatic injury is a major public health threat that requires
continuous searching for new effective therapeutics. KSG (Kaempferol-3-sophoroside-7 …

Thymoquinone attenuates acetaminophen overdose-induced acute liver injury and inflammation via regulation of JNK and AMPK signaling pathway

BW Cui, T Bai, Y Yang, Y Zhang, M Jiang… - The American Journal …, 2019 - World Scientific
Thymoquinone (TQ) is a main aromatic component of Nigella sativa L. seeds or Agastache
rugosa (Fisch. & CA Mey.) Kuntze. The protective mechanism of TQ against acute liver injury …

Salvianolic acid C against acetaminophen‐induced acute liver injury by attenuating inflammation, oxidative stress, and apoptosis through inhibition of the Keap1/Nrf2 …

CT Wu, JS Deng, WC Huang, PC Shieh… - Oxidative medicine …, 2019 - Wiley Online Library
Acetaminophen (APAP) overdose is one of the most common causes of drug‐induced acute
liver failure in humans. To investigate the hepatoprotective effect of salvianolic acid C (SAC) …

Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway

D Yu, J Li, Y Wang, D Guo, X Zhang… - Drug Development …, 2023 - Wiley Online Library
Acetaminophen (APAP) overdose‐induced acute liver injury (ALI) causes hepatocyte cell
death, oxidative stress, and inflammation. Oridonin (Ori), a covalent NLRP3‐inflammasome …

Protective effects and possible molecular mechanism of Hovenia dulcis Thunb. extract on acetaminophen-induced hepatotoxicity

S Dong, J Ji, B Zhang, L Hu, X Cui… - Die Pharmazie-An …, 2018 - ingentaconnect.com
Hovenia dulcis Thunb. is a traditional hepatoprotective Chinese medicine, and in research,
much effort has been focused on the protection against alcoholic liver injury. In this study …