In this study, acetaminophen (APAP)-induced acute liver injury mice model was used to
investigate the effects of C2-ceramide and oltipraz on hepatocyte nuclear factor 1 (HNF-1) …

Aims Acetaminophen (APAP) overdose leads to severe hepatotoxicity. Isoquercitrin
exhibited potential hepatoprotective effect in our previous study. The present investigation …

Background: Acetaminophen (APAP) overdose results in the production of reactive oxygen
species (ROS), induces hepatocyte necrosis, and leads to acute liver failure. Atractylenolide …

Acetaminophen (APAP) is a widely used over-the-counter drug for antipyretic and analgesic,
but an overdose will induce acute liver injury. APAP hepatotoxicity has been the most …

AIM: To investigate the in vivo hepatoprotective effects and mechanisms of Gentiana
manshurica Kitagawa (GM) in acetaminophen (APAP)-induced liver injury in mice …

Acute liver failure induced by acetaminophen (APAP) overdose is the main cause of drug-
induced liver injury (DILI). Caffeic acid (CA) is a phenolic compound from many natural …

We investigated the mechanism of lophirones B‐and C‐mediated protection against
acetaminophen hepatotoxicity. Mice were pretreated with 20 mg/kg body weight lophirones …

Background Acetaminophen (APAP) is a conventional drug widely used in the clinic
because of its antipyretic-analgesic effects. However, accidental or intentional APAP …

APAP is one of the most commonly used antipyretic and pain medications, but excessive
use can cause liver toxicity and damage. 3, 4-dihydroxyphenylethyl alcohol glycoside (DAG) …

Schisandra sphenanthera is widely used as a tonic and restorative in many countries to
enhance the function of liver and other organs. Wuzhi tablet (WZ) is a preparation of an …