In this study, we have examined the correlation between the histological and histochemical
changes of articular cartilage and bone parameters of the underlying subchondral bone. The …

Objective Although most research investigating the pathogenesis of osteoarthritis (OA) has
focused on cartilage, it has been suggested that the subchondral bone (SCB) plays an …

The present study has focused on the cartilage‐bone interrelationships in the progression of
osteoarthrosis in human knees. Eleven tibial condyles with osteoarthrosis were analyzed by …

Osteoarthritis is traditionally associated with cartilage degeneration although is now widely
accepted as a whole-joint disease affecting the entire osteochondral unit; however site …

OBJECTIVE: To examine the relationship between structural changes of trabecular bone
and cartilage, in patients with varying degrees of osteoarthritis (OA) over 2 years, using …

OBJECTIVE: This study aimed to investigate the spatial and temporal subchondral bone
change of Dunkin–Hartley (DH) strain guinea pigs spontaneous osteoarthritis (OA) model at …

The microstructural characteristics of osteoarthritic subchondral bone in the medial tibial
condyle are clearly different from normal age-matched bone. Subchondral sclerosis in …

OBJECTIVE: Substantial changes in articular cartilage composition and mechanical
properties occur during the development of osteoarthritis (OA). While softening in the initial …

Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA)
pathogenesis, little is known about local changes in bone structure compared to cartilage …

Objective Osteoarthritis (OA) has often regarded as a disease of articular cartilage only. New
evidence has shifted the paradigm towards a system biology approach, where also the …