Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …

Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play
important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In …

The cytochromes P450 (CYPs) constitute a superfamily of hemoprotein enzymes that are
responsible for the biotransformation of numerous xenobiotics, including therapeutic agents …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Recent advances in the study of human cytochromes P450 by protein purification, molecular
cloning techniques and analysis of polymorphisms has led to increased understanding of …

The cytochrome P450 family is a large and diverse group of hemoproteins that are located in
virtually all types of organism, such as bacteria, eukaryotes and even Archaea. These …

Of 57 functional human cytochrome P450 (CYP) isoforms, about a dozen liver‐expressed,
highly variable forms are responsible for the biotransformation of most drugs. Owing to …

The cytochrome P450 (CYP) enzyme system is involved in the metabolism and elimination
of numerous widely used drugs. The capacity of this system varies from one person to …

Highlights•The interindividual variability of CYP2C members and its impact in drug
metabolism are reviewed.•Current advances in molecular modeling of CYP2C …