Background Artemisinin-combination therapy (ACT) is recommended as first-line treatment
of falciparum malaria throughout the world, and fixed-dose combinations are preferred by …

Background Artemisinin and partner-drug resistance in Plasmodium falciparum are major
threats to malaria control and elimination. Triple artemisinin-based combination therapies …

Background The choice of appropriate artemisinin-based combination therapy depends on
several factors (cost, efficacy, safety, reinfection rate and simplicity of administration). To …

Background Artemisinin-based combinations are judged the best treatments for multidrug-
resistant Plasmodium falciparum malaria. Artesunate-mefloquine is widely recommended in …

Background The efficacy of artemisinin-based combination therapy has already been
demonstrated in a number of studies all over the world, and some of them can be regarded …

Summary Background The burden of Plasmodium vivax infections has been
underappreciated, especially in southeast Asia where chloroquine resistant strains have …

Background The use of drug combinations, including non-artemisinin-based and artemisinin-
based combination therapy (ACT), is a novel strategy that enhances therapeutic efficacy and …

Background The artemisinin-based combination treatment (ACT) of dihydroartemisinin
(DHA) and piperaquine (PQP) is a promising novel anti-malarial drug effective against multi …

Background Artemisinin-based combination regimens are widely advocated for malarial
treatment, but other effective regimens might be cheaper and more readily available. Our …

Background Late treatment failures after artemisinin-based combination therapies (ACTs) for
falciparum malaria have increased in the Greater Mekong subregion in southeast Asia …