Abstract Active Freeze Drying allows for producing lyophilised powders by progressive
agitation of frozen blocks undergoing sublimation. One potential application of this process …

This work reviews the examples of the application of lyophilization and its cryogenic
modifications as the production method of solid dispersions and drug nanocrystals, two …

Drug nanoparticles prepared in a liquid medium are commonly freeze-dried for the
preparation of an oral dosage in solid dosage form. The freezing rate is known to be a …

Recent advances in nanoparticle technologies have significantly enhanced the oral and
parenteral delivery of poorly water-soluble active pharmaceutical ingredients (APIs) …

The present study investigates whether controlling the product temperature below the critical
formulation temperature (CFT) during primary drying in a freeze drying cycle is a …

In a previous study we have developed a novel process to produce drug nanocrystals. This
process,“controlled crystallization during freeze-drying” has shown to be a successful …

To improve the dissolution behavior of lipophilic drugs, a novel bottom–up process based
upon freeze drying which allows for the production of nanocrystalline particles was …

It has been recently reported in the literature that using a fast freezing rate during freeze-
drying of drug nanosuspensions is beneficial to preserve the original particle size …

The aim of this work was to systematically study the effect of freeze-drying of bottom-up
processed cilostazol nanosuspension on the particle size after redispersion. Several …

Nanocrystalline suspensions offer a promising approach to improve dissolution of BCS class
II/IV compounds. Spray drying was utilized as a downstream process to improve the physical …