The cardiovascular and electrophysiological effects of amiodarone resemble those of
hypothyroidism. The drug has a structural resemblance to thyroid hormone (T3). Previous …

Abstract Background and Objective Amiodarone (AMD) is one of the most effective drugs for
rhythm control of atrial fibrillation. The use of AMD is also associated with adverse effects in …

Objectives. To review the historical development of amiodarone and the changing
perceptions of the drug, and discuss its electrophysiologic, pharmacologic, and …

Metoprolol is a selective β‐1 adrenergic receptor blocker that undergoes extensive
metabolism by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6). Our objective …

The objective of this study was to determine whether patients enrolled in a centralized
amiodarone monitoring service (AMS) were more adherent to amiodarone surveillance and …

The dataset presented here provides a detailed description of the adverse events of
amiodarone versus placebo using data from 43 randomized controlled trials. Two authors …

Methods Between January 1, 2000 and March 10, 2012, a total of 930 consecutive patients
who had been treated with amiodarone for arrhythmia were reviewed retrospectively. An …

The limited value of in vitro toxicity data for the in vivo extrapolation has been often attributed
to the lack of kinetic data. Here the in vitro kinetics of amiodarone (AMI) and its mono-N …

Therapy for HIV often can make pharmacologic management of comorbidities challenging
since many antiretroviral agents significantly modulate drug metabolism pathways …

Amiodarone was initially developed in the early 1960s as a treatment for angina pectoris,
since it produces coronary vasodilation and decreases cardiac oxygen demand. However …