Natural estrogens such as estradiol (E2) or its valerate ester (E2V) offer an alternative to
ethinyl estradiol (EE). E2-containing combined oral contraceptives (COCs) have …

Previous attempts to replace ethinylestradiol (EE) with 17β-estradiol (E2) in combined oral
contraceptives (COCs) have proved unsatisfactory in terms of bleeding outcomes. A review …

BACKGROUND: Estradiol valerate/dienogest (E2V/DNG) is a combined oral contraceptive
(COC) with 2 new hormonal entities and a unique 4-phasic dosing regimen indicated for …

Objective: To review the pharmacology, pharmacokinetics, efficacy, and safety of the new
oral contraceptive estradiol valerate/dienogest. Data Sources: Searches of PubMed (1966 …

BACKGROUND: Attempts to improve the tolerability of combined oral contraceptives (COCs)
have included the substitution of ethinylestradiol (EE) with 17β-estradiol (E2). However, this …

Abstract▴ Estradiol valerate/dienogest is an oral contraceptive for women that combines the
natural estrogen estradiol with the 19-nortestosterone derivative dienogest in a four-phasic …

The need to seek improved combined oral contraceptive (COC) efficacy, with fewer health
risks and better acceptability, has been ongoing since the introduction of COCs more than …

Background: This study investigated the efficacy and safety of a combined oral contraceptive
(COC) containing estradiol valerate/dienogest (E2V/DNG). Methods: This was a multicenter …

Progestogens in combined oral contraceptives for contraception Page 1 Progestogens in
combined oral contraceptives for contraception (Review) Maitra NN, Kulier R, Bloemenkamp K …

Combined oral contraceptives formulated to include estradiol (E2) have recently become
available for the indication of pregnancy prevention. A combined estradiol valerate and …