Most combination oral contraceptives contain ethinyl estradiol and a progestin. A new and
novel oral contraceptive formulation combines estradiol valerate (E2V) with dienogest …

BACKGROUND: The estrogen step-down/progestogen step-up 28-day estradiol
valerate/dienogest (E2V/DNG) oral contraceptive effectively inhibits ovulation; however …

OBJECTIVE: A novel oral contraceptive (OC) that contains oestradiol valerate (E2V; 1mg of
E2V is equivalent to 0.76 mg of 17beta-oestradiol) and dienogest (DNG) has been …

Context Limited studies have compared the effects of combined oral contraceptives (COCs)
containing natural estrogens and synthetic ethinylestradiol (EE) on reproductive hormones …

Objective To summarise all clinical data on the contraceptive efficacy and bleeding profile
associated with an oestradiol valerate (E2V) and dienogest (DNG)[E2V/DNG] combined oral …

Over the last 55 years, the traditional pill has constantly evolved. After the early attempts with
mestranol, the use of ethinyl-estradiol (EE) became predominant for decades until a few …

Objective: To highlight studies that investigated the efficacy, safety, and tolerability of low-
dose oral contraceptives (OCs) containing 20 μg of ethinyl estradiol (EE) and to discuss the …

BACKGROUND: This study compared the bleeding pattern, cycle control and safety of an
oral contraceptive (OC) comprising estradiol valerate/dienogest (E2V/DNG; administered …

Introduction The evolution of contraception has been crucial for public health and
reproductive well-being. Over the past 60 years, combined oral contraceptives (COCs) have …

Dienogest (DNG) has the essential properties of an effective progestogen for use in a new
contraceptive pill using estradiol valerate as estrogenic component–it inhibits ovulation and …