A phase II randomized trial of amphotericin B alone or combined with fluconazole in the treatment of HIV-associated cryptococcal meningitis
PG Pappas, P Chetchotisakd, RA Larsen… - Clinical infectious …, 2009 - academic.oup.com
Background. Cryptococcosis is a life-threatening infection among patients with human
immunodeficientcy virus (HIV) infection. Therapeutic options for the treatment of central …
immunodeficientcy virus (HIV) infection. Therapeutic options for the treatment of central …
[HTML][HTML] Treatment of Cryptococcal meningitis: how have we got here and where are we going?
NTT Ngan, B Flower, JN Day - Drugs, 2022 - Springer
Cryptococcal meningitis is a devastating brain infection cause by encapsulated yeasts of the
Cryptococcus genus. Exposure, through inhalation, is likely universal by adulthood, but …
Cryptococcus genus. Exposure, through inhalation, is likely universal by adulthood, but …
Combination antifungal therapy for cryptococcal meningitis
Background Combination antifungal therapy (amphotericin B deoxycholate and flucytosine)
is the recommended treatment for cryptococcal meningitis but has not been shown to reduce …
is the recommended treatment for cryptococcal meningitis but has not been shown to reduce …
Management of cryptococcal meningitis in sub-Saharan Africa
A Jackson, MC Hosseinipour - Current HIV/AIDS Reports, 2010 - Springer
Cryptococcal meningitis (CM) is a common form of meningitis in sub-Saharan Africa due to
the high prevalence of HIV/AIDS. This report outlines the management of CM with a focus on …
the high prevalence of HIV/AIDS. This report outlines the management of CM with a focus on …
How applicable is the single-dose ambition regimen for human immunodeficiency virus–associated cryptococcal meningitis to high-income settings?
TS Harrison, DS Lawrence… - Clinical Infectious …, 2023 - academic.oup.com
Abstract The AmBisome Therapy Induction Optimization (AMBITION-cm) trial, conducted in
eastern and southern Africa, showed that a single, high dose (10 mg/kg) of liposomal …
eastern and southern Africa, showed that a single, high dose (10 mg/kg) of liposomal …
Cryptococcal meningitis
Cryptococcus neoformans and Cryptococcus gattii species complexes cause
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …
Therapy for cryptococcal meningitis in patients with AIDS
WG Powderly - Clinical infectious diseases, 1992 - academic.oup.com
Abstract Treatment of cryptococcal meningitis in patients with AIDS with amphotericin B plus
flucytosine is associated with a failure rate of 20%–30%. In the absence of chronic …
flucytosine is associated with a failure rate of 20%–30%. In the absence of chronic …
[HTML][HTML] CryptoDex: a randomised, double-blind, placebo-controlled phase III trial of adjunctive dexamethasone in HIV-infected adults with cryptococcal meningitis …
Background Cryptococcal meningitis (CM) is a severe AIDS-defining illness with 90-day
case mortality as high as 70% in sub-Saharan Africa, despite treatment. It is the leading …
case mortality as high as 70% in sub-Saharan Africa, despite treatment. It is the leading …
Therapy of cryptococcal meningitis in non-HIV-infected patients
PG Pappas - Current Infectious Disease Reports, 2001 - Springer
Cryptococcus neoformans is the most common cause of fungal meningitis in HIV and non-
HIV-infected patients. The organism has a worldwide distribution, with cases typically …
HIV-infected patients. The organism has a worldwide distribution, with cases typically …
Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial
Background: Interferon-gamma (IFNγ) is of key importance in the immune response to
Cryptococcus neoformans. Mortality related to cryptococcal meningitis remains high, and …
Cryptococcus neoformans. Mortality related to cryptococcal meningitis remains high, and …