Drugs Active at Tâ•’type Ca²⁺ Channels Page 1 5.2 Drugs Active at T-type Ca2+
Channels Thomas M. Connolly and James C. Barrow 5.2.1 Introduction A typical cell lives …

Calcium-activated potassium channels are a heterogeneous family of channels that, despite
their different biophysical characteristics, structures, and pharmacological signatures, play a …

A subset of potassium channels is regulated primarily by changes in the cytoplasmic
concentration of ions, including calcium, sodium, chloride, and protons. The eight members …

Low-voltage–activated T-type Ca 2+ channelsare present in most excitable tissues including
the heart (mainly pacemakercells), smooth muscle, central and peripheral nervous systems …

T type calcium channels are implicated in a fascinating array of physiological and
pathophysiological phenomena, as reviewed extensively in this issue of Cell Calcium. It is …

The kidney plays a pivotal role in regulating calcium levels within the body. Approximately
98% of the filtered calcium is reabsorbed in the nephron, and this process is tightly …

▪ Abstract The identification of the epithelial Ca2+ channel (ECaC) complements the group
of Ca2+ transport proteins including calbindin-D28K, Na+/Ca2+ exchanger and plasma …

Objectives: In this publication, we review the definitions, symptoms, causes, differential
diagnoses and therapies of hypokalemia and hyperkalemia. Methods: Comprehensive …

The kidneys play a vital role in mineral homeostasis. In this review, the handling of calcium
and the methods currently applied to measuring its intracellular concentration are discussed …

Intracellular calcium (Ca2+) signals are of prime importance for cellular function and
behavior and are underpinned by a plethora of Ca2+ channels, pumps, transporters, and …