Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice

T Shang, L Liu, J Zhou, M Zhang, Q Hu, M Fang… - Lipids in Health and …, 2017 - Springer
Background A sedentary lifestyle and poor diet are risk factors for the progression of non-
alcoholic fatty liver disease. However, the pathogenesis of hepatic lipid accumulation is not …

Dietary DHA/EPA Ratio Changes Fatty Acid Composition and Attenuates Diet‐Induced Accumulation of Lipid in the Liver of ApoE−/− Mice

L Liu, Q Hu, H Wu, X Wang, C Gao… - Oxidative Medicine …, 2018 - Wiley Online Library
Diets containing various docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) ratios
protect against liver damage in mice fed with a high‐fat diet (HFD). However, it is unclear …

Different effects of eicosapentaenoic and docosahexaenoic acids on atherogenic high-fat diet-induced non-alcoholic fatty liver disease in mice

N Suzuki-Kemuriyama, T Matsuzaka, M Kuba, H Ohno… - PloS one, 2016 - journals.plos.org
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome,
can progress to steatohepatitis (NASH) and advanced liver damage, such as that from liver …

Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of nonalcoholic fatty liver disease

MN Stanković, DR Mladenović, I Đuričić… - Archives of Medical …, 2014 - Elsevier
Background and Aims Methionine-choline deficient (MCD) diet duration necessary for
development of non-alcoholic fatty liver disease (NAFLD) and the dynamic of lipid profile …

Ability of high fat diet to induce liver pathology correlates with the level of linoleic acid and Vitamin E in the diet

DS Graham, G Liu, A Arasteh, XM Yin, S Yan - PLoS One, 2023 - journals.plos.org
Increased uptake of fat, such as through the ingestion of high fat diet (HFD), can lead to fatty
liver diseases and metabolic syndrome. It is not clear whether certain fatty acids may be …

Effects of a diet rich in n-3 polyunsaturated fatty acids on hepatic lipogenesis and beta-oxidation in mice

TCL Bargut, EDC Frantz, CA Mandarim-de-Lacerda… - Lipids, 2014 - Springer
Here, we investigate whether a diet rich in fish oil can lead to the development of hepatic
alterations associated with non-alcoholic fatty liver disease (NAFLD). To achieve this goal …

Eicosapentaenoic and docosahexaenoic acid-enriched high fat diet delays the development of fatty liver in mice

NK Soni, I Nookaew, AS Sandberg… - Lipids in health and …, 2015 - Springer
Background Low hepatic content of n-3 PUFA has been associated with NAFLD in humans.
Whether this is associated with reduced dietary intake or increased turnover of these FA is …

Comparison of the effects of monounsaturated fatty acids and polyunsaturated fatty acids on liver lipid disorders in obese mice

W Liu, M Zhu, M Gong, W Zheng, X Zeng, Q Zheng, X Li… - Nutrients, 2023 - mdpi.com
Obesity is a recognized epidemic worldwide, and the accumulation of excess free saturated
fatty acids (SFAs) in cells induces cellular lipotoxic damage and increases the risk of a wide …

[HTML][HTML] Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr−/− mouse model of western …

CM Depner, KA Philbrick, DB Jump - The Journal of nutrition, 2013 - Elsevier
The incidence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis
(NASH) has increased in parallel with the incidence of obesity. While both NAFLD and …

Soybean oil-derived poly-unsaturated fatty acids enhance liver damage in NAFLD induced by dietary cholesterol

J Henkel, E Alfine, J Saín, K Jöhrens, D Weber… - Nutrients, 2018 - mdpi.com
While the impact of dietary cholesterol on the progression of atherosclerosis has probably
been overestimated, increasing evidence suggests that dietary cholesterol might favor the …