The impact of next-generation sequencing technology on genetics

ER Mardis - Trends in genetics, 2008 - cell.com
If one accepts that the fundamental pursuit of genetics is to determine the genotypes that
explain phenotypes, the meteoric increase of DNA sequence information applied toward that …

Coming of age: ten years of next-generation sequencing technologies

S Goodwin, JD McPherson, WR McCombie - Nature reviews genetics, 2016 - nature.com
Since the completion of the human genome project in 2003, extraordinary progress has
been made in genome sequencing technologies, which has led to a decreased cost per …

Next-generation DNA sequencing methods

ER Mardis - Annu. Rev. Genomics Hum. Genet., 2008 - annualreviews.org
Recent scientific discoveries that resulted from the application of next-generation DNA
sequencing technologies highlight the striking impact of these massively parallel platforms …

Beyond assembly: the increasing flexibility of single-molecule sequencing technology

PW Hook, W Timp - Nature Reviews Genetics, 2023 - nature.com
The maturation of high-throughput short-read sequencing technology over the past two
decades has shaped the way genomes are studied. Recently, single-molecule, long-read …

Next-generation sequencing strategies

SE Levy, BE Boone - Cold Spring Harbor …, 2019 - perspectivesinmedicine.cshlp.org
More than a decade ago, the term “next-generation” sequencing was coined to describe
what was, at the time, revolutionary new methods to sequence RNA and DNA at a faster …

Next-generation sequencing data interpretation: enhancing reproducibility and accessibility

A Nekrutenko, J Taylor - Nature Reviews Genetics, 2012 - nature.com
Areas of life sciences research that were previously distant from each other in ideology,
analysis practices and toolkits, such as microbial ecology and personalized medicine, have …

A vision for the future of genomics research

FS Collins, ED Green, AE Guttmacher, MS Guyer… - nature, 2003 - nature.com
A vision for the future of genomics research | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

An integrated framework for discovery and genotyping of genomic variants from high-throughput sequencing experiments

J Duitama, JC Quintero, DF Cruz… - Nucleic acids …, 2014 - academic.oup.com
Recent advances in high-throughput sequencing (HTS) technologies and computing
capacity have produced unprecedented amounts of genomic data that have unraveled the …

Next-generation sequencing—an overview of the history, tools, and “Omic” applications

JK Kulski - Next generation sequencing-advances, applications …, 2016 - books.google.com
Next-generation sequencing (NGS) technologies using DNA, RNA, or methylation
sequencing have impacted enormously on the life sciences. NGS is the choice for large …

SNP discovery and genotyping for evolutionary genetics using RAD sequencing

PD Etter, S Bassham, PA Hohenlohe… - Molecular methods for …, 2011 - Springer
Next-generation sequencing technologies are revolutionizing the field of evolutionary
biology, opening the possibility for genetic analysis at scales not previously possible …