Natural antibodies against phosphorylcholine in cardiovascular disease
U De Faire, J Frostegård - Annals of the New York Academy of …, 2009 - Wiley Online Library
Atherosclerosis is a chronic inflammatory disease characterized by the presence of activated
immune‐competent cells in the lesions, producing mainly proinflammatory cytokines …
immune‐competent cells in the lesions, producing mainly proinflammatory cytokines …
Low level natural antibodies against phosphorylcholine: a novel risk marker and potential mechanism in atherosclerosis and cardiovascular disease
J Frostegård - Clinical immunology, 2010 - Elsevier
Atherosclerosis is an inflammatory condition characterised by an abundance of activated
immunocompetent cells in plaques which cause cardiovascular disease (CVD) when they …
immunocompetent cells in plaques which cause cardiovascular disease (CVD) when they …
Antibodies against phosphorylcholine and protection against atherosclerosis, cardiovascular disease and chronic inflammation
J Frostegård - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
Introduction Chronic inflammatory diseases include cardiovascular disease (CVD),
atherosclerosis, rheumatic and autoimmune diseases, and others, constituting a large part of …
atherosclerosis, rheumatic and autoimmune diseases, and others, constituting a large part of …
Low levels of natural IgM antibodies against phosphorylcholine are independently associated with vascular remodeling in patients with coronary artery disease
CA Gleissner, C Erbel, J Haeussler… - Clinical Research in …, 2015 - Springer
Low anti-phosphorylcholine (PC) IgM plasma levels have been associated with increased
incidence of adverse events in coronary artery disease (CAD). The underlying mechanisms …
incidence of adverse events in coronary artery disease (CAD). The underlying mechanisms …
Low levels of IgM antibodies against phosphorylcholine—a potential risk marker for ischemic stroke in men
BG Sjöberg, J Su, I Dahlbom, H Grönlund, M Wikström… - Atherosclerosis, 2009 - Elsevier
BACKGROUND: Natural antibodies specific for phosphorylcholine (anti-PC) have been
implicated as protective factors in atherosclerosis. We herein determined the relationship …
implicated as protective factors in atherosclerosis. We herein determined the relationship …
Lysophosphatidylcholine is involved in the antigenicity of oxidized LDL
R Wu, YH Huang, LS Elinder… - … thrombosis, and vascular …, 1998 - Am Heart Assoc
Lysophosphatidylcholine (LPC) is formed by hydrolysis of PC in low density lipoprotein
(LDL) and cell membranes by phospholipase A2 or by oxidation. Oxidized (ox) LDL …
(LDL) and cell membranes by phospholipase A2 or by oxidation. Oxidized (ox) LDL …
Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases
MR de Vries, MM Ewing, RCM de Jong… - Journal of Internal …, 2021 - Wiley Online Library
Background Phosphorylcholine (PC) is an important pro‐inflammatory damage‐associated
molecular pattern. Previous data have shown that natural IgM anti‐PC protects against …
molecular pattern. Previous data have shown that natural IgM anti‐PC protects against …
Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden
R Fiskesund, B Stegmayr, G Hallmans, M Vikström… - Stroke, 2010 - Am Heart Assoc
Background and Purpose—Natural immunoglobulin M antibodies specific for
phosphorylcholine (anti-PC) have been implicated in atherosclerosis. We have shown …
phosphorylcholine (anti-PC) have been implicated in atherosclerosis. We have shown …
Antibodies against phosphorylcholine among New Guineans compared to Swedes: an aspect of the hygiene/missing old friends hypothesis
J Frostegård, WJ Tao, L Råstam… - Immunological …, 2017 - Taylor & Francis
Background: We here study antibodies against phosphorylcholine (anti-PC) which we
reported to be inversely associated with atherosclerosis, cardiovascular disease (CVD), and …
reported to be inversely associated with atherosclerosis, cardiovascular disease (CVD), and …
Low levels of IgM antibodies against phosphorylcholine predict development of acute myocardial infarction in a population-based cohort from northern Sweden
H Grönlund, G Hallmans, JH Jansson… - European Journal of …, 2009 - academic.oup.com
Objective Phosphorylcholine (PC) is one important epitope on oxidized low-density
lipoprotein that may play an important role by contributing to the atherogenicity of oxidized …
lipoprotein that may play an important role by contributing to the atherogenicity of oxidized …
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