The intravenous delivery of disease-relevant antigens (Ag) by polymeric nanoparticles (NP-
Ags) has demonstrated Ag-specific immune tolerance in autoimmune and allergic disorders …

Tolerogenic nanoparticles (NPs) are rapidly being developed as specific immunotherapies
to treat autoimmune disease. However, many NP-based therapies conjugate antigen (Ag) …

Immune‐mediated hypersensitivities such as autoimmunity, allergy, and allogeneic graft
rejection are treated with therapeutics that suppress the immune system, and the lack of …

The development of nanomaterials to induce antigen-specific immune tolerance has shown
promise for treating autoimmune diseases. While PEGylation has been widely used to …

Autoimmune diseases affect many people worldwide. Current treatment modalities focus on
the reduction of disease symptoms using anti-inflammatory drugs which can lead to side …

Abstract Poly (γ-glutamic acid)(γ-PGA) nanoparticles (NPs) carrying antigens have been
shown to induce potent antigen-specific immune responses. However, in vivo delivery of γ …

Nanoparticles are considered to be efficient tools for inducing potent immune responses by
an Ag carrier. In this study, we examined the effect of Ag-carrying biodegradable poly (γ …

Targeted approaches to treat autoimmune diseases would improve upon current therapies
that broadly suppress the immune system and lead to detrimental side effects. Antigen …

Polymeric nanoparticles (NPs) have demonstrated their potential to induce antigen (Ag)-
specific immunological tolerance in multiple immune models and are at various stages of …

Current strategies for treating autoimmunity involve the administration of broad-acting
immunosuppressive agents that impair healthy immunity. Intravenous (iv) administration of …