Vascular permeability regulated by the vascular endothelial growth factor (VEGF) through
endothelial-barrier junctions is essential for inflammation. Mechanisms regulating vascular …

Although numerous studies have implicated Akt and Src kinases in vascular endothelial
growth factor (VEGF) and Angiopoietin‐1 (Ang‐1)‐induced endothelial‐barrier regulation, a …

The PI3K/Akt pathway is necessary for several key endothelial cell (EC) functions, including
cell growth, migration, survival, and vascular tone. However, existing literature supports the …

Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …

Objective—The importance of PI3K/Akt signaling in the vasculature has been demonstrated
in several models, as global loss of Akt1 results in impaired postnatal ischemia-and VEGF …

Regulation of endothelial cell apoptosis is a critical modulator of normal and pathological
angiogenesis. In this study, we examined the role of the protein kinase Akt/PKB in …

Endothelial to mesenchymal transition (EndMT), where endothelial cells acquire
mesenchymal characteristics has been implicated in several cardiopulmonary, vascular and …

Tissue factor (TF) has been shown to be up‐regulated in endothelial cells by the
inflammatory cytokine tumor necrosis factor a (TNF‐α) as well as by the main angiogenic …

Protein kinase B (Akt1) holds a central role for cellular growth, development, and survival,
but the cellular pathways of Akt1 that prevent inflammatory demise in the vascular system …

The central role of VEGF (vascular endothelial growth factor A) in angiogenesis is
dependent upon its ability to co-ordinately regulate multiple endothelial functions. The …