In this issue of Cancer Cell, Phung and coworkers demonstrate that sustained endothelial
activation of Akt by expression of constitutively activated Akt1 (myrAkt1) leads to blood …

The endothelial barrier consists of intercellular contacts localized in the cleft between
endothelial cells, which is covered by the glycocalyx in a sievelike manner. Both types of …

Angiogenesis is critical for many physiological and pathological processes. To identify
molecules relevant to angiogenesis, we performed a proteomic screen comparing invading …

Retinal angiogenesis was delayed in VSMC-specific Akt1-deficient mice (Akt1∆ SMC) but
not in Akt2∆ SMC mice. The proliferation of ECs, recruitment of pericytes, and coverage of …

Transient disruption of endothelial adherens junctions and cytoskeletal remodeling are
responsible for increases in vascular permeability induced by inflammatory stimuli and …

RhoGTPases control endothelial cell (EC) migration, adhesion, and barrier formation.
Whereas the relevance of RhoA for endothelial barrier function is widely accepted, the role …

The endothelium is required for maintenance of vascular integrity and homeostasis during
vascular development and in adulthood. However, little is known about the coordinated …

Vascular endothelial growth factor (VEGF) and Ang1 (Angiopoietin-1) have opposing effects
on vascular permeability, but the molecular basis of these effects is not fully known. We …

Cell-to-cell junctions are critical for the formation of endothelial barriers, and its
disorganization is required for sprouting angiogenesis. Members of the angiomotin (AMOT) …

Etk/Bmx is a member of the Tec family of cytoplasmic non-receptor tyrosine kinases known
to express in epithelial cells. We demonstrate herein that Etk activation in stably Etk …