A large number of chemicals may exert adverse effects on the central and/or peripheral
nervous system. A commonly recommended strategy for neurotoxicity testing is that of a …

Risk assessment is a process often divided into the following steps: a) hazard identification,
b) dose-response assessment, c) exposure assessment, and d) risk characterization …

This review presents some of the newer techniques in the rapidly advancing area of
neurotoxicity testing in vitro. They are not described at length, and more details can be …

Prediction of neurotoxic effects is a key feature in the toxicological profile of many
compounds and therefore is required by regulatory testing schemes. Nowadays …

In vitro systems have been proposed, but not yet demonstrated, as a method to assess the
neurotoxicity of compounds in an efficient and rapid manner. Although such tests are …

This review provides a scientific view on how to evaluate effectively the neurotoxic potential
of chemicals in order to provide adequate safeguards for human health. Detection of …

This is the report of the third of a series of workshops organised by the European Centre for
the Validation of Alternative Methods (ECVAM). ECV AM's main goal, as defined in 1993 by …

Neurotoxicology is a relatively young discipline that has undergone significant growth during
the last 25 years. During the late 1970s and 1980s, numerous national and international …

The neurotoxicological potential of a compound is best evaluated with information from a
wide variety of tests. Our philosophy is that tests should be applicable across species and …

Developmental neurotoxicity is any effect of a toxicant on the developing nervous system
before or after birth that interferes with normal nervous system structure or function …