The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …

Several candidate gene studies have provided evidence for a role of host genetics in
susceptibility to tuberculosis (TB). However, the results of these studies have been very …

Only a small fraction of individuals exposed to Mycobacterium tuberculosis develop clinical
tuberculosis (TB). Over the past century, epidemiological studies have shown that human …

The historical impression that tuberculosis was an inherited disorder has come full circle and
substantial evidence now exists of the human genetic contribution to susceptibility to …

There is substantial evidence that host genetic factors are important in determining
susceptibility to mycobacteria. Several different techniques have been used to identify the …

The importance of host genetic factors in determining susceptibility to tuberculosis (TB) has
been studied extensively using various methods, such as case‐control, candidate gene and …

Genetic factors are important contributors to the development of a wide range of complex or
multifactorial diseases. For example, if one has a close relative who died of ischemic heart …

Tuberculosis is an ancient human disease, estimated to have originated and evolved over
thousands of years alongside modern human populations. Despite considerable advances …

Tuberculosis, a chronic infectious disease caused by Mycobacterium tuberculosis, has
reemerged as a leading public health problem. Approximately one-third of the world's …

Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …