In contrast to VEGF and its receptor VEGFR-2, PlGF and its receptor VEGFR-1 have been
largely neglected and therefore their potential for therapy has not been previously explored …

Placental growth factor (PlGF) belongs to the same family as the vascular endothelial growth
factor A (VEGF-A). Recent gene inactivation studies in mice have demonstrated that loss of …

Efforts to therapeutically stimulate or inhibit vessel growth have been primarily focused on
vascular endothelial growth factor (VEGF) and its receptor VEGFR‐2 (Flk‐1), while little …

Angiogenesis is a complex biological phenomenon crucial for a correct embryonic
development and for post-natal growth. In adult life, it is a tightly regulated process confined …

The placental growth factor (PlGF) is an angiogenic protein belonging to the vascular
endothelial growth factor (VEGF) family, which was discovered in 1991 by an Italian …

Accumulating evidences have documented that angiogenesis is closely linked to
inflammation and regulators of angiogenesis play key roles in various inflammatory …

Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF
receptor-2 (VEGFR-2). The role of its homolog, placental growth factor (PlGF), remains …

Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF)
family that also comprises VEGF-A (VEGF), VEGF-B, VEGF-C, and VEGF-D. Unlike VEGF …

The needs of the uterus and the fetus for the provision of nutrients and oxygen, supplied by
the blood flow, are understandably extremely high, with the circulatory system playing the …

Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF)
family, comprising at least five cytokines specifically involved in the regulation of vascular …