MG53 nucleates assembly of cell membrane repair machinery
Dynamic membrane repair is essential not only for long-term maintenance of cellular
integrity but also for recovery from acute cell injury. While compromised membrane repair …
integrity but also for recovery from acute cell injury. While compromised membrane repair …
Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair
M Hwang, J Ko, N Weisleder… - American Journal of …, 2011 - journals.physiology.org
We recently discovered that MG53, a muscle-specific tripartite motif (TRIM) family protein,
functions as a sensor of oxidation to nucleate the assembly of cell membrane repair …
functions as a sensor of oxidation to nucleate the assembly of cell membrane repair …
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy
N Weisleder, N Takizawa, P Lin, X Wang… - Science translational …, 2012 - science.org
Mitsugumin 53 (MG53), a muscle-specific TRIM family protein, is an essential component of
the cell membrane repair machinery. Here, we examined the translational value of targeting …
the cell membrane repair machinery. Here, we examined the translational value of targeting …
Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
MG53 is a muscle-specific TRIM-family protein that presides over the cell membrane repair
response. Here, we show that MG53 present in blood circulation acts as a myokine to …
response. Here, we show that MG53 present in blood circulation acts as a myokine to …
[HTML][HTML] Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair
Repair of injury to the plasma membrane is an essential mechanism for maintenance of
cellular homeostasis and integrity that involves coordinated movement of intracellular …
cellular homeostasis and integrity that involves coordinated movement of intracellular …
Polymerase Transcriptase Release Factor (PTRF) Anchors MG53 Protein to Cell Injury Site for Initiation of Membrane Repair*♦
Plasma membrane repair is an essential process for maintenance of homeostasis at the
cellular and tissue levels, whereas compromised repair capacity contributes to degenerative …
cellular and tissue levels, whereas compromised repair capacity contributes to degenerative …
Enhancing muscle membrane repair by gene delivery of MG53 ameliorates muscular dystrophy and heart failure in δ-Sarcoglycan-deficient hamsters
Muscular dystrophies (MDs) are caused by genetic mutations in over 30 different genes,
many of which encode for proteins essential for the integrity of muscle cell structure and …
many of which encode for proteins essential for the integrity of muscle cell structure and …
MG53 regulates membrane budding and exocytosis in muscle cells
Membrane recycling and remodeling contribute to multiple cellular functions, including cell
fusion events during myogenesis. We have identified a tripartite motif (TRIM72) family …
fusion events during myogenesis. We have identified a tripartite motif (TRIM72) family …
Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
SH Park, J Han, BC Jeong, JH Song, SH Jang… - Nature Structural & …, 2023 - nature.com
Defects in plasma membrane repair can lead to muscle and heart diseases in humans.
Tripartite motif-containing protein (TRIM) 72 (mitsugumin 53; MG53) has been determined to …
Tripartite motif-containing protein (TRIM) 72 (mitsugumin 53; MG53) has been determined to …
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair
Rationale: Unrepaired cardiomyocyte membrane injury causes irreplaceable cell loss,
leading to myocardial fibrosis and eventually heart failure. However, the cellular and …
leading to myocardial fibrosis and eventually heart failure. However, the cellular and …