Novel anti-cancer effect of 2-arachidonoylglycerol via processing body formation in HCA-7 human colon cancer cells

T Misao, K Fukushima, H Fujino - Prostaglandins & Other Lipid Mediators, 2024 - Elsevier
Abstract The endocannabinoid 2-arachidonoylglycerol (2-AG) has been reported to exhibit
anticancer effects, including against colorectal cancer (CRC); however, the detailed …

[HTML][HTML] Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice

J Jehle, B Schöne, S Bagheri, E Avraamidou… - PLoS …, 2018 - journals.plos.org
Background The endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) is a known
modulator of inflammation and ligand to both, pro-inflammatory cannabinoid receptor 1 …

2-Arachidonoylglycerol in Cardiovascular Disease: Angel or Demon?

J Cui, Q Zhang, Y Fan - Cardiovascular Drugs and Therapy, 2023 - Springer
Recently, an interesting study entitled “2-Arachidonoylglycerol Attenuates Myocardial
Fibrosis in Diabetic Mice Via the TGF-β1/Smad Pathway” was published in Cardiovascular …

Various acylglycerols from common oils exert different antitumor activities on colorectal cancer cells

RP Ramos-Bueno, MJ González-Fernández… - Nutrition and …, 2016 - Taylor & Francis
Colorectal cancer is one of the leading causes of death in Western countries; therefore, the
implementation of healthy dietary habits in order to prevent its occurrence is a desirable …

Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor‐independent reactive oxygen species

SW Park, JE Kim, SM Oh, WJ Cha, JH Hah… - Head & …, 2015 - Wiley Online Library
Background The endocannabinoids, anandamide (AEA) and 2‐arachidonoyl glycerol (2‐
AG), are considered promising potential anticancer agents. In this study, we examined the …

Anti-proliferative effect of a putative endocannabinoid, 2-arachidonylglyceryl ether in prostate carcinoma cells

K Nithipatikom, MA Isbell, MP Endsley… - Prostaglandins & other …, 2011 - Elsevier
Endocannabinoids (ECs), anandamide (AEA) and 2-arachidonoylglycerol (2-AG), inhibit
proliferation of carcinoma cells. Several enzymes hydrolyze ECs to reduce endogenous EC …

COX-2-derived endocannabinoid metabolites as novel inflammatory mediators

M Alhouayek, GG Muccioli - Trends in pharmacological sciences, 2014 - cell.com
Cyclooxygenase-2 (COX-2) is an enzyme that plays a key role in inflammatory processes.
Classically, this enzyme is upregulated in inflammatory situations and is responsible for the …

Diverse roles of 2‐arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12‐lipoxygenase metabolism

MP Endsley, N Aggarwal, MA Isbell… - … journal of cancer, 2007 - Wiley Online Library
Abstract Endogenous 2‐arachidonoylglycerol (2‐AG) is antiinvasive in androgen‐
independent prostate carcinoma (PC‐3) cells. Invasion of PC‐3 cells is also inhibited by …

[HTML][HTML] 5-lipoxygenase mediates docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine-induced reactive oxygen species production and inhibition of …

SW Park, JH Hah, SM Oh, WJ Jeong, MW Sung - BMC cancer, 2016 - Springer
Background Endocannabinoids have recently drawn attention as promising anti-cancer
agents. We previously observed that anandamide (AEA), one of the representative …

Novel anti-inflammatory and vasodilatory ω-3 endocannabinoid epoxide regioisomers

LN Carnevale, A Das - The Role of Bioactive Lipids in Cancer …, 2019 - Springer
Accumulating evidence suggests that diets rich in ω-3 polyunsaturated fatty acids (PUFAs)
offer protection against vascular inflammation, neuroinflammation, hypertension, and …