[HTML][HTML] A threonine residue in the seventh transmembrane domain of the human A1 adenosine receptor mediates specific agonist binding.
A Townsend-Nicholson, PR Schofield - Journal of Biological Chemistry, 1994 - Elsevier
The A1 adenosine receptor is a member of the seven-transmembrane G protein-coupled,
receptor superfamily. This receptor binds the purine nucleoside adenosine with high affinity …
receptor superfamily. This receptor binds the purine nucleoside adenosine with high affinity …
Site-directed Mutagenesis Identifies Residues Involved in Ligand Recognition in the Human A2a Adenosine Receptor∗
J Kim, J Wess, AM van Rhee, T Schöneberg… - Journal of Biological …, 1995 - ASBMB
The A 2a adenosine receptor is a member of the G-protein coupled receptor family, and its
activation stimulates cyclic AMP production. To determine the residues which are involved in …
activation stimulates cyclic AMP production. To determine the residues which are involved in …
Serine and alanine mutagenesis of the nine native cysteine residues of the human A1 adenosine receptor
DJ Scholl, JN Wells - Biochemical pharmacology, 2000 - Elsevier
To examine the importance of the nine native cysteine residues in the human A1 adenosine
receptor, each cysteine was individually mutated to both serine and alanine. Saturation …
receptor, each cysteine was individually mutated to both serine and alanine. Saturation …
[PDF][PDF] Site-directed mutagenesis of the human A1 adenosine receptor: influences of acidic and hydroxy residues in the first four transmembrane domains on ligand …
H Barbhaiya, R McCLAIN, A Ijzerman… - Molecular pharmacology, 1996 - Citeseer
To provide new insights into ligand/A1 adenosine receptor(A1 AR) interactions, site-directed
mutagenesis was used to test the role of several residues in the first four …
mutagenesis was used to test the role of several residues in the first four …
[HTML][HTML] A binding site model and structure-activity relationships for the rat A3 adenosine receptor
PJM Van Galen, AH VAN BERGEN… - Molecular …, 1994 - ncbi.nlm.nih.gov
SUMMARY A novel adenosine receptor, the A 3 receptor, has recently been cloned. We
have systematically investigated the hitherto largely unexplored structure-activity …
have systematically investigated the hitherto largely unexplored structure-activity …
Structure and function of A1 adenosine receptors1
J Linden - The FASEB journal, 1991 - Wiley Online Library
The A1 adenosine receptor is the best characterized of the widely distributed purinergic
receptor family. The purified brain A1 receptor is a monomeric 35‐to 36‐kDa glycoprotein …
receptor family. The purified brain A1 receptor is a monomeric 35‐to 36‐kDa glycoprotein …
[HTML][HTML] The A1 adenosine receptor. Solubilization and characterization of a guanine nucleotide-sensitive form of the receptor.
GL Stiles - Journal of Biological Chemistry, 1985 - Elsevier
Adenosine acting through membrane-bound A1 receptors is capable of inhibiting the
enzyme adenylate cyclase. A1 adenosine receptors from rat cerebral cortex have been …
enzyme adenylate cyclase. A1 adenosine receptors from rat cerebral cortex have been …
Ligand binding and subtype selectivity of the human A2A adenosine receptor: identification and characterization of essential amino acid residues
The crystal structure of the human A 2A adenosine receptor bound to the A 2A receptor-
specific antagonist, ZM241385, was recently determined at 2.6-Å resolution. Surprisingly …
specific antagonist, ZM241385, was recently determined at 2.6-Å resolution. Surprisingly …
[HTML][HTML] Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors.
ME Olah, KA Jacobson, GL Stiles - Journal of Biological Chemistry, 1994 - Elsevier
Adenosine receptor (AR) agonists and antagonists are approximately 100-fold and 100,000-
fold, respectively, more potent at the bovine A1AR as compared to the rat A3AR. To …
fold, respectively, more potent at the bovine A1AR as compared to the rat A3AR. To …
Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.
QY Zhou, C Li, ME Olah, RA Johnson… - Proceedings of the …, 1992 - National Acad Sciences
We have previously reported the selective amplification of several rat striatal cDNA
sequences that encode guanine nucleotide-binding regulatory protein (G protein)-coupled …
sequences that encode guanine nucleotide-binding regulatory protein (G protein)-coupled …
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- threonine residue adenosine receptor
- transmembrane domains adenosine receptor
- agonist and antagonist adenosine receptors
- alanine mutagenesis adenosine receptor
- molecular cloning adenosine receptor
- subtype selectivity adenosine receptor
- ligand recognition adenosine receptor
- cysteine residues adenosine receptor