The A1 adenosine receptor is a member of the seven-transmembrane G protein-coupled,
receptor superfamily. This receptor binds the purine nucleoside adenosine with high affinity …

The A 2a adenosine receptor is a member of the G-protein coupled receptor family, and its
activation stimulates cyclic AMP production. To determine the residues which are involved in …

To examine the importance of the nine native cysteine residues in the human A1 adenosine
receptor, each cysteine was individually mutated to both serine and alanine. Saturation …

To provide new insights into ligand/A1 adenosine receptor(A1 AR) interactions, site-directed
mutagenesis was used to test the role of several residues in the first four …

SUMMARY A novel adenosine receptor, the A 3 receptor, has recently been cloned. We
have systematically investigated the hitherto largely unexplored structure-activity …

The A1 adenosine receptor is the best characterized of the widely distributed purinergic
receptor family. The purified brain A1 receptor is a monomeric 35‐to 36‐kDa glycoprotein …

Adenosine acting through membrane-bound A1 receptors is capable of inhibiting the
enzyme adenylate cyclase. A1 adenosine receptors from rat cerebral cortex have been …

The crystal structure of the human A 2A adenosine receptor bound to the A 2A receptor-
specific antagonist, ZM241385, was recently determined at 2.6-Å resolution. Surprisingly …

Adenosine receptor (AR) agonists and antagonists are approximately 100-fold and 100,000-
fold, respectively, more potent at the bovine A1AR as compared to the rat A3AR. To …

We have previously reported the selective amplification of several rat striatal cDNA
sequences that encode guanine nucleotide-binding regulatory protein (G protein)-coupled …