Treatment of sulfur mustard (HD)‐induced lung injury

DR Anderson, SL Byers… - Journal of Applied …, 2000 - Wiley Online Library
An in vivo sulfur mustard (HD) vapor exposure model followed by bronchoalveolar lavage
was developed previously in this laboratory to study biochemical indicators of HD‐induced …

Pathologic changes in rat lungs following acute sulfur mustard inhalation

DR Anderson, JJ Yourick, RB Moeller… - Inhalation …, 1996 - Taylor & Francis
Although the majority of deaths resulting from exposure to sulfur mustard (HD) have been
due to pulmonary dysfunction, there are no detailed accounts of the pathogenesis of HD …

Inhalation exposure to sulfur mustard in the guinea pig model: clinical, biochemical and histopathological characterization of respiratory injuries

N Allon, A Amir, E Manisterski, I Rabinovitz… - Toxicology and applied …, 2009 - Elsevier
Guinea pigs (GP) were exposed (head only) in individual plethysmographs to various
concentrations of sulfur mustard vapor, determined online, using FTIR attached to flow …

Toxicity of sulphur mustard in adult rat lung organ culture

TW Sawyer, PE Wilde, P Rice, MT Weiss - Toxicology, 1995 - Elsevier
The toxicity of the chemical warfare agent sulphur mustard,(bis-(2-chloroethyl) sulphide,
HD), was examined in adult rat lung organ cultures. Assessment of HD-induced damage by …

Progressive lung injury, inflammation, and fibrosis in rats following inhalation of sulfur mustard

R Malaviya, EV Abramova, RC Rancourt… - Toxicological …, 2020 - academic.oup.com
Sulfur mustard (SM) inhalation causes debilitating pulmonary injury in humans which
progresses to fibrosis. Herein, we developed a rat model of SM toxicity which parallels …

Exposure–response effects of inhaled sulfur mustard in a large porcine model: a 6-h study

SJ Fairhall, BJA Jugg, RW Read, SJ Stubbs… - Inhalation …, 2010 - Taylor & Francis
Context: Inhalation of sulfur mustard (HD) vapor can cause life-threatening lung injury for
which there is no specific treatment. A reproducible, characterized in vivo model is required …

Inflammatory effects of inhaled sulfur mustard in rat lung

R Malaviya, VR Sunil, J Cervelli, DR Anderson… - Toxicology and applied …, 2010 - Elsevier
Inhalation of sulfur mustard (SM), a bifunctional alkylating agent that causes severe lung
damage, is a significant threat to both military and civilian populations. The mechanisms …

Mechanism underlying acute lung injury due to sulfur mustard exposure in rats

Z Xiaoji, M Xiao, X Rui, C Haibo… - Toxicology and …, 2016 - journals.sagepub.com
Sulfur mustard (SM), a bifunctional alkylating agent that causes severe lung damage, is a
significant threat to both military and civilian populations. The mechanisms mediating the …

Inhalation exposure systems for the development of rodent models of sulfur mustard-induced pulmonary injury

WM Weber, DA Kracko, MR Lehman… - Toxicology …, 2010 - Taylor & Francis
Sulfur mustard (SM) is a chemical threat agent for which its effects have no current treatment.
Due to the ease of synthesis and dispersal of this material, the need to develop therapeutics …

Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity

B Weinberger, JD Laskin, VR Sunil, PJ Sinko… - Pulmonary …, 2011 - Elsevier
Sulfur mustard (SM) is highly toxic to the lung inducing both acute and chronic effects
including upper and lower obstructive disease, airway inflammation, and acute respiratory …