Exophthalmos together with goiter was perhaps first described by 12th century Persian
physician Sayyid Ismail al-Jurjani (1). Robert Graves discussed that hyperthyroid condition …

We have previously proposed that proinflammatory cytokines and nitric oxide (NO)
contributed to the reversible myocardial depression and beta-adrenergic desensitization …

Bench research has contributed a great deal to advances in critical care medicine. Early
work in animals provided insight into the pathobiology of critical illness and was the testing …

Baseball was frazzled and frustrated. He had left the ivory tower of academe to lead the
favorite American pastime and looked forward to what promised to be a matching of …

First, the cerebral survival study (2) is said to have shown cerebral necrosis in patients who
met the Harvard criteria (n 102). The study was done from 1970 to 1972 with 501 patients (a …

In this issue of Critical Care Med-icine, Ackland and colleagues (1) report findings from a
series of experiments, using blockade in rodent models of endotoxic shock and sepsis …

Cortisol is often considered the quintessential stress hormone. It has been shown to
increase after a variety of stressors, and the response is typically proportional to the …

First, the cerebral survival study (2) is said to have shown cerebral necrosis in patients who
met the Harvard criteria (n 102). The study was done from 1970 to 1972 with 501 patients (a …

As intensivists we like the idea of giving a drug to reduce the risk of morbidity and death. The
practice fits in well with our overall role in protecting patients by close attention to detail and …

Generalization is both the boon and bane of clinical investigation. The ability to take
disparate results from a number of different experiments or clinical findings and apply them …