Mouse studies have been instrumental in forming our current understanding of early cell-
lineage decisions; however, similar insights into the early human development are severely …

Following implantation, the epiblast (EPI) cells transit from the naive to primed pluripotency,
accompanied by dynamic changes in X chromosome activity in females. To investigate the …

Pluripotency, differentiation, and X Chromosome inactivation (XCI) are key aspects of
embryonic development. However, the underlying relationship and mechanisms among …

Understanding lineage specification during human pre-implantation development is a
gateway to improving assisted reproductive technologies and stem cell research. Here we …

Single-cell profiling techniques create opportunities to delineate cell fate progression in
mammalian development. Recent studies have provided transcriptome data from human pre …

Single-cell epigenome sequencing techniques have recently been developed. However, the
combination of different layers of epigenome sequencing in an individual cell has not yet …

Here, we provide fundamental insights into early human development by single-cell RNA-
sequencing of human and mouse preimplantation embryos. We elucidate conserved …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

Extensive epigenetic reprogramming occurs during preimplantation embryo development.
However, it remains largely unclear how the drastic epigenetic reprogramming contributes to …

Measuring gene expression in individual cells is crucial for understanding the gene
regulatory network controlling human embryonic development. Here we apply single-cell …