Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis

PJ Little, A Chait, A Bobik - Pharmacology & therapeutics, 2011 - Elsevier
Cardiovascular disease is the largest cause of morbidity and premature mortality and its
major underlying pathology is atherosclerosis. Atherosclerosis commences with the …

[HTML][HTML] Atherosclerosis: the involvement of immunity, cytokines and cells in pathogenesis, and potential novel therapeutics

C Su, Y Lu, Z Wang, J Guo, Y Hou, X Wang… - Aging and …, 2023 - ncbi.nlm.nih.gov
As a leading contributor to coronary artery disease (CAD) and stroke, atherosclerosis has
become one of the major cardiovascular diseases (CVD) negatively impacting patients …

Inflammatory mechanisms in atherosclerosis

D Wolf, P Stachon, C Bode, A Zirlik - Hämostaseologie, 2014 - thieme-connect.com
Throughout the last two decades inflammation has been recognized as the central
mechanism underlying atherogenesis. A multitude of basic science work demonstrates the …

Role of inflammation and immune response in atherosclerosis: Mechanisms, modulations, and therapeutic targets

F Liu, Y Wang, J Yu - Human Immunology, 2023 - Elsevier
Cardiovascular diseases (CVDs) have emerged as the leading cause of mortality globally,
with atherosclerosis being a prominent focus of investigation among medical researchers …

Key roles of inflammation in atherosclerosis: Mediators involved in orchestrating the inflammatory response and its resolution in the disease along with therapeutic …

YH Chan, DP Ramji - Atherosclerosis: Methods and Protocols, 2022 - Springer
Inflammation is a critical driver of all stages of atherosclerosis, from lesion development to
plaque rupture. Cytokines are mediators of the immune response and in atherosclerosis, the …

Molecular and cellular mechanisms of inflammation in atherosclerosis

NM Popa-Fotea, CE Ferdoschi… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis and its complications are a major cause of morbidity and mortality worldwide
in spite of the improved medical and invasive treatment in terms of revascularization …

Atherosclerosis—Underlying inflammatory mechanisms and clinical implications

S Patel, DS Celermajer, S Bao - The international journal of biochemistry & …, 2008 - Elsevier
Inflammation plays an important role in the initiation and progression of atherosclerosis but
many of its underlying mechanisms remain to be explored. Atherosclerotic plaques which …

Inflammatory cytokines in atherosclerosis: current therapeutic approaches

D Tousoulis, E Oikonomou, EK Economou… - European heart …, 2016 - academic.oup.com
The notion of atherosclerosis as a chronic inflammatory disease has intensified research on
the role of cytokines and the way these molecules act and interact to initiate and sustain …

Evolving concepts in the triad of atherosclerosis, inflammation and thrombosis

R Corti, R Hutter, JJ Badimon, V Fuster - Journal of thrombosis and …, 2004 - Springer
Recent developments into antherothrombosis, the leading cause of morbidity and mortality
in Western Society, may help to change our treatment strategy to a more casual approach …

Targeting inflammation in cardiovascular diseases. still a neglected field?

C Gómez‐Guerrero, B Mallavia… - Cardiovascular …, 2012 - Wiley Online Library
Prevention and treatment of atherosclerosis is still a clinical challenge in the cardiovascular
medicine. The classical belief that atherosclerotic lesion development solely depends on …