Osteosarcoma is the most common primary malignant bone tumor in children and
adolescents, with highly aggressive behavior and early systemic metastasis. The survival …

Bone and soft tissue sarcomas account for approximately 15% of pediatric solid malignant
tumors and 1% of adult solid malignant tumors. There are over 50 subtypes of sarcomas …

The cure rate of osteosarcoma has not improved in the past 30 years. The new treatments
and drugs is urgently needed, especially for metastatic osteosarcoma. Anti-angiogenesis …

Tumor cells recruit vascular endothelial cells and circulating endothelial progenitor cells to
form new vessels to support their own growth and metastasis. VEGF, PDGF-BB and FGF-2 …

Angiogenesis has an essential role in tumor growth and metastasis, and blocking this
pathway has been a successfully utilized strategy in the clinical treatment of cancer …

Osteosarcoma is a highly common malignant bone tumor. Its highly metastatic properties are
the leading cause of mortality for cancer. Niclosamide, a salicylanilide derivative, is an oral …

Abstract Background Tyrosine kinase inhibitors (TKIs) such as cabozantinib, regorafenib
have demonstrated encouraging activity in prolonging progression‐free survival (PFS) in …

Background Anlotinib is a highly potent multi-target tyrosine kinase inhibitor, with very good
anti-tumor activity against a variety of solid tumors. However, its effect on colorectal cancer …

Purpose Anlotinib protects against carcinogenesis through the induction of autophagy and
apoptosis. The current study evaluated the role and molecular mechanisms of anlotinib in …

The survival rate of osteosarcoma, the most prevalent primary bone tumor, has not been
effectively improved in the last 30 years. Hence, new treatments and drugs are urgently …