Abstract Background/Aims: Renal stone disease may be seen as a clinical symptom of an
underlying pathological process predisposing to crystallization within the renal tract. Renal …

Several animal species are used to study calcium oxalate urolithiasis; however, an ideal
model has yet to be identified. We used Drosophila as a model organism and fed the flies …

PURPOSE: In this systematic review we summarize information on animal models of stone
formation, the similarities of stone formation between humans and nonhuman animals, and …

Randall's plaques (RP) are well established as precursor lesions of idiopathic calcium
oxalate (CaOx) stones, and the process of biomineralization driven by osteogenic-like cells …

Zinc is an essential metal that is involved in a wide range of biological processes, and
aberrant zinc homeostasis is implicated in multiple human diseases. Cadmium is chemically …

Oxalate is a major component of the most common form of kidney stones—calcium oxalate
stones. High concentrations of oxalate promote stone formation in two ways:(1) by providing …

Renal stone formation (nephrolithiasis) is a worldwide problem causing substantial
morbidity and economic burden. The heritability of stone formation has long been …

Kidney stone disease is a common disorder in Western countries that is associated with
significant suffering, morbidity, and cost for the healthcare system. Numerous studies have …

Ectopic calcification (EC), which is the pathological deposition of calcium and phosphate in
extra-skeletal tissues, may be associated with hypercalcaemic and hyperphosphataemic …

Disturbed zinc (Zn) homeostasis in mammals is mainly characterized by impaired bone
generation accompanied with growth retardation. However, the underlying mechanisms that …